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Evonik
Recent advances in biopolymer-based mucoadhesive drug delivery systems for oral application
Oral drug delivery is a common and convenient route for administering pharmaceuticals, but it presents challenges related to drug stability, absorption, and targeted delivery. Because of their potential to address these challenges, biopolymer-based mucoadhesive drug delivery systems have received a…
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Experimental design approach for Development of Carboplatin Loaded Chitosan Modified Liposomal…
One of the most prevalent cancers affecting women globally is cervical cancer. Cervical cancer is thought to cause 570.000 new cases annually, and standard treatments can have serious side effects. In this work main aim is to design, fabrication and evaluation of carboplatin loaded chitosan coated…
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Co-processed materials testing as excipients to produce Orally Disintegrating Tablets (ODT) using…
The use of co-processed materials for Orally Disintegrating Tablets (ODT) preparation by direct compression is well consolidated. However, the evaluation of their potential for ODT preparation by 3D printing technology remains almost unexplored. The present study aimed to estimate the use of…
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Physicochemical reports of gliclazide-carplex solid dispersions and tablets prepared with directly…
Abstract
Objectives
The main goal of this research was to develop better tablet formulations by utilizing solid dispersions (SDs) and coprocessing excipients composite to achieve a better release rate of poor water-soluble gliclazide.
Methods
The solvent evaporation method made SDs of…
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Phase homogeneity in ternary amorphous solid dispersions and its impact on solubility, dissolution…
Abstract
As performance of ternary amorphous solid dispersions (ASDs) depends on the solid-state characteristics and polymer mixing, a comprehensive understanding of synergistic interactions between the polymers in regard of dissolution enhancement of poorly soluble drugs and subsequent…
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Visualizing disintegration of 3D printed tablets in humans using MRI and comparison with in vitro…
Three-dimensional (3D) printing is revolutionising the way that medicines are manufactured today, paving the way towards more personalised medicine. However, there is limited in vivo data on 3D printed dosage forms, and no studies to date have been performed investigating the intestinal behaviour of…
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Pre and post characterization of ODTs with emphasis on compression force and quality of…
Oral dispersible tablets (ODTs) are patient compliant dosage forms which rapidly disintegrate in the mouth following active absorption with rapid onset of action. The current study was designed to resolve compression problems used for ODTs, as high compression force exhibited hardness and drug…
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Comparison of Two Grafted Copolymers, Soluplus and Kollicoat IR, as Solid Dispersion Carriers of…
Arteether (ART), an antimalarial drug, belongs to BCS class II and has very low oral bioavailability. Clinically, it is given as a solution in oil by the intramuscular route. Solid dispersion in Soluplus or Kollicoat IR, two commonly used grafted copolymers, may improve its in vitro dissolution and…
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A pH-sensitive silica nanoparticles for colon-specific delivery and controlled release of catechin:…
Catechin is a naturally occurring flavonoid of the flavan-3-ol subclass with numerous biological functions; however, these benefits are diminished due to several factors, including low water solubility and degradation in the stomach's harsh environment. So, this study aimed to develop an intelligent…
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Aerogels as Carriers for Oral Administration of Drugs: An Approach towards Colonic Delivery
Polysaccharide aerogels have emerged as a highly promising technology in the field of oral drug delivery. These nanoporous, ultralight materials, derived from natural polysaccharides such as cellulose, starch, or chitin, have significant potential in colonic drug delivery due to their unique…
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