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Glatt
Hybrid models to support development of fluid bed granulation processes
Abstract
The hybrid modeling strategy which is based on the integration of mechanistic and data-driven models is proposed and applied on fluidized bed granulation processes. The tight combination of empirical process knowledge by means of a mechanistic model and the multivariate data from PAT…
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Taste-Masked Pellets of Warfarin Sodium: Formulation towards the Dose Personalisation
Abstract
The bitter drug, warfarin, has a narrow therapeutic index (NTI) and is used in paediatrics and geriatrics. The aim of this feasibility study was to formulate the taste-masked warfarin-containing pellets to be applicable for dose personalisation and to improve patient compliance, as well as…
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Effects of omitting titanium dioxide from the film coating of a pharmaceutical tablet
An industrial case study of attempting to comply with EU regulation 2022/63
Recently, concerns have been raised about the safety of titanium dioxide (TiO2), a commonly used component of pharmaceutical film coatings. The European Union has recently prohibited the application of this material in the…
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Engineering of Highly Drug Loaded, Free-Flowing Mini-Particles via Tangential Spray Fluid Bed…
This poster was presented at the PBP World Meeting 2024 by Glatt Pharmaceutical Services with the Utrecht Institute for Pharmaceutical Sciences:
Introduction
Personalized medicine combines various approaches to establish therapy regimens that are tailored to individual patients. In oral drug…
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Continuous Manufacturing of Highly Drug Loaded Matrix Pellets by ProCell® Technology
This poster by Glatt Pharmaceutical Services was presented at the PBP World Meeting 2024:
Introduction
ProCell® Technology is a continuous spouted bed pelletization process which allows the manufacture of pellets with very high active drug loadings (> 95 %) and narrow particle size…
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Influence of refilling on dosing accuracy of loss-in-weight powder feeders in continuous…
Abstract
Continuous manufacturing is a novel concept to produce high quality drug products. The manufacture of solid dosage forms starts with the feeding of materials, which is consider a critical step because it could have a high influence on the quality of the final product. Therefore, this unit…
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Drying liquids – Selecting the best technology for nutraceuticals
The desired end product properties can make a difference when choosing between spray drying or spray granulation
Both spray drying and fluid bed spray granulation can be used to convert liquid products into bulk materials. The most effective process will often be dictated by the desired properties…
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Exploring new ways to produce cosmetic pigments – Interview with Merck and Glatt about the…
Using completely new technology, pigment specialists at Merck and Glatt Ingenieurtechnik’s technology and production experts have worked closely together to produce an innovative range of cosmetic pigments. The Darmstadt-based Merck Group placed an order for the development and construction of a…
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Accessing amorphous solid dispersions for improved Solubility and Bioavailability in paediatric…
This article shows the content of a poster which was presented at the 𝗘𝗨𝗣𝗳𝗜 𝗰𝗼𝗻𝗳𝗲𝗿𝗲𝗻𝗰𝗲 𝗶𝗻 𝗚𝗹𝗮𝘀𝗴𝗼𝘄 2023
Introduction
BCS class II drugs show a low solubility. Modern paediatric formulations are needed to obtain high acceptance of patients at recommended daily doses
Hot-melt extrusion (HME)…
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Taste Masked Artesunate/Amodiaquine Micropellets in the Fight Against Malaria
This article shows the content of a poster which was presented at the 𝗘𝗨𝗣𝗳𝗜 𝗰𝗼𝗻𝗳𝗲𝗿𝗲𝗻𝗰𝗲 𝗶𝗻 𝗚𝗹𝗮𝘀𝗴𝗼𝘄 2023
Malaria & Treatment Challenges
Children aged under 5 years are the worst affected by malaria, causing about 10 % of all children’s deaths in regions where malaria is endemic. Fixed dose…
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