Grace

The aim of this work was to compare mesoporous carriers based on silica and magnesium aluminosilicate in the amorphous solid dispersion production. Darunavir has been selected as an active pharmaceutical ingredient that is classified as a Class 2 BCS substance and exists in two commercially…
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Purpose Drug X is high solubility, high permeability BCS/DCS I small molecule drug. High dose and potential pediatric indication required multiparticulate formulation with not less than 80% drug loading to achieve flexible and low quantity dosing with potential for modified release…
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EXCiPACT asbl is pleased to announce that the W. R. Grace site in Baltimore, Maryland, USA has recently been awarded an EXCiPACT GMP Certificate from SGS, one of EXCIPACT’s internationally recognised Certification Bodies. The Certificate demonstrates that this site manufactures silicon dioxyde as…
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Poor aqueous solubility of terpenophenolic compound Cannabidiol (CBD) is a major issue in the widespread use of this promising therapeutic polyphenol. Moreover, choosing the appropriate strategy to overcome this challenge is time-consuming and based on trial–error processes. The amorphous form of…
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In this paper, the role of mesoporous silica (MS) particle size in the stabilization of amorphous simvastatin (SVT) is revealed. For inhibiting recrystallization of the supercooled drug, the two MS materials (Syloid® XDP 3050 and Syloid® 244 FP) were employed. The crystallization tendency of SVT…
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Despite the increasing interest in pharmaceutical use of mesoporous silica, there is still only limited knowledge on mechanisms of pore loading and subsequent drug desorption and release. Hence the aim of this work was to address the mechanistic aspects of drug loading into the mesoporous silica…
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Many functional substances are hardly dissolved in water or lipid at ambient temperature, which causes some difficulties in product formulation. Therefore, the aim of this research was to develop a novel carrier system by complexing nanostructured lipid carriers (NLC) with mesoporous silica…
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Flow aid additives are commonly used in industries to improve the processing of cohesive powders. A wide variety of additives are available: magnesium or calcium stearate, fumed and mesoporous silica, talc, etc. The efficiency of the additive depends on the cohesive forces playing a role in the…
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In recent years mesoporous silica is gaining attention because of their emerging applications in drug delivery. Since their first appearance in materials science in the 1990s, these inorganic carriers have been successfully used in other areas such as catalysis, purification, and adsorption. The…
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Direct compression is not only a topic in continuous manufacturing but in pharmaceutical production in general.  In direct compression the physical characteristics of the excipients have a major impact on the processes ability of the formulation. Topics like flowability, bulk density and…
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