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Water-insoluble polymers as binders for pellet drug layering: Effect on drug release and performance…
The objective of this study was to investigate the applicability of water-insoluble polymers as binders for pellets drug layering to extend the drug release.
Carbamazepine was layered on sugar cores in fluidized bed coater using isopropanol (IPA):water solution or aqueous dispersion of…
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Gastroresistant gelatin films prepared by addition of cellulose acetate phthalate
09. June 2017
Abstract
Gastroresistant capsules are obtained mostly by using modified-release fill in hard capsules, or by coating the gelatin shell with acid-resistant polymers. Modification of the material used at the stage when the capsule shell is produced would reduce the…
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Multispectral UV imaging for surface analysis of MUPS tablets with special focus on the pellet…
04. October 2016
Abstract
In the present study the applicability of multispectral UV imaging in combination with multivariate image analysis for surface evaluation of MUPS tablets was investigated with respect to the differentiation of the API pellets from the excipients matrix,…
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AN INVESTIGATION INTO TASTE MASKING OF A MICRONIZEDPARACETAMOL USING AQUACOAT® ECD APPLIED VIA…
INTRODUCTION AND PURPOSE
Taste masking is a very important step in the development of paediatric medications such as oral suspensions and tablets for products with APIs that are bitter or unpalatable. In this study, taste masking of a bitter, micronized API model (Paracetamol) was…
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Microcrystalline cellulose, a direct compression binder in a quality by design environment—A review
The ICH quality vision introduced the concept of quality by design (QbD), which requires a greater understanding of the raw material attributes, of process parameters, of their variability and their interactions. Microcrystalline cellulose (MCC) is one of the most important tableting excipients…
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