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IFF
In Situ Gelling Nasal Drug Delivery System
Abstract
In the nasal cavity, nasal mucosa had a high blood perfusion rate, due to this the absorption of the drug is high as compared to other routes, as well as has increased good bioavailability of drugs at the systemic circulation. To improve the nasal retention time of in-situ gel with nasal…
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Development of novel portable NIR spectroscopy process analytical technology (PAT) tool for…
The aim of this research was to develop a process analytical technology (PAT) tool for monitoring the transformation process of the active ingredient ibuprofen into the fast-dissolving salt ibuprofen sodium during the wet granulation process. Two near-infrared (NIR) spectrophotometers, namely…
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IFF Unveils its Controlled Release Platform Featuring its Innovation and Trailblazing Excipients
PRESS RELEASE
NEW YORK —May 15, 2024 — IFF (NYSE: IFF), a global leader in food and beverage, home and personal care and health, today announced a new controlled release platform for its portfolio of controlled release products including METHOCEL™, ETHOCEL™, and POLYOX™. Under the banner,…
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Spray drying Eudragit® E-PO with acetaminophen using 2- and 3-fluid nozzles for taste masking
Conventional spray drying using a 2-fluid nozzle forms matrix microparticles, where drug is distributed throughout the particle and may not effectively mask taste. In contrast, spray drying using a 3-fluid nozzle has been reported to encapsulate material. The objective of this study was to spray dry…
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Taste-Masked Pellets of Warfarin Sodium: Formulation towards the Dose Personalisation
Abstract
The bitter drug, warfarin, has a narrow therapeutic index (NTI) and is used in paediatrics and geriatrics. The aim of this feasibility study was to formulate the taste-masked warfarin-containing pellets to be applicable for dose personalisation and to improve patient compliance, as well as…
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Formulation development, in-vitro and ex-vivo evaluation of dry adsorbed solid lipid nanoparticles:…
Abstract
Aim: The present study was aimed at preparing stable dry adsorbed nanoparticles (DANs) of olanzapine (OLZ) loaded solid lipid nanoparticles (SLNs) for sustained release.
Materials/methods: OLZ SLNs were prepared by hot melt emulsification and ultrasonication using Precirol ATO 5 (PRE)…
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Paediatric clinical study of 3D printed personalised medicines for rare metabolic disorders
Rare diseases are infrequent, but together they affect up to 6–10 % of the world’s population, mainly children. Patients require precise doses and strict adherence to avoid metabolic or cardiac failure in some cases, which cannot be addressed in a reliable way using pharmaceutical compounding. 3D…
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Development and application of control concepts for twin-screw wet granulation in the ConsiGma-25:…
Abstract
Traditional operation modes, such as running the production processes at constant process settings or within a narrow design space, do not fully exploit the advantages of continuous pharmaceutical manufacturing. Integrating Quality by Control (QbC) algorithms as a standard component of…
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Polymeric microspheres redefining the landscape of colon-targeted delivery: A contemporary update
Abstract
During recent times, the delivery of the medications to the colon has seen more interest by the researchers, as it proved to be providing both options for treating local colon-related conditions and a route for systemic delivery of the various other types of medications. For these to…
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Novel fast dissolving freeze dried sublingual baicalin tablets for enhanced hepatoprotective effect:…
Baicalin (BG), a natural product, has been used in the prevention and treatment of drug-induced liver injury (DILI); however, its poor solubility and extensive liver metabolism limit its pharmacological use. The aim of the present study was the formulation of fast-dissolving freeze-dried sublingual…
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