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Correlating mechanical and rheological filament properties to processability and quality of 3D…
Filament formulation for FDM is a challenging and time-consuming process. Several pharmaceutical polymers are not feedable on their own. Due to inadequate filament formulation, 3D printed tablets can also exhibit poor uniformity of tablet attributes. To better understand filament formulation…
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Successful Formulation Window for the design of pharmaceutical tablets with required mechanical…
Abstract
Pharmaceutical tablet formulations combine the active ingredient with processing aids and functional components. This paper evaluates compressibility based predictive models for binary and ternary formulations to establish an acceptable range of tablet compression parameters that satisfy…
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Effect of Croscarmellose Sodium in Sustained Release Layer of Valsartan in Bilayer Tablet with…
The aim of the study was to design and evaluate bilayer tablets of clopidogrel as immediate release and quick relief and valsartan for sustained release and check the effect of croscarmellose sodium (2%) in Carbopol for sustained release action. Bilayer tablets was prepared using direct compression…
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Orodispersible Films: Current Innovations and Emerging Trends
Abstract
Orodispersible films (ODFs) are thin, mechanically strong, and flexible polymeric films that are designed to dissolve or disintegrate rapidly in the oral cavity for local and/or systemic drug delivery. This review examines various aspects of ODFs and their potential as a drug delivery…
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Characterizing a design space for a twin-screw wet granulation process: A case study of…
Abstract
Twin-screw wet granulation is an emerging continuous manufacturing technology for solid oral dosage forms. This technology has been successfully employed for the commercial manufacture of immediate-released tablets. However, the higher polymer content in extended-release (ER) formulations…
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Pre and post characterization of ODTs with emphasis on compression force and quality of…
Oral dispersible tablets (ODTs) are patient compliant dosage forms which rapidly disintegrate in the mouth following active absorption with rapid onset of action. The current study was designed to resolve compression problems used for ODTs, as high compression force exhibited hardness and drug…
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Effect of magnesium stearate solid lipid nanoparticles as a lubricant on the properties of tablets…
Abstract
This study discusses the lubricant properties of magnesium stearate solid lipid nanoparticles (MgSt-SLN) and their effect on the tabletability, mechanical properties, disintegration, and acetaminophen-model dissolution time of microcrystalline cellulose (MCC) tablets prepared by direct…
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Determination of Gastric Water Emptying in Fasted and Fed State Conditions Using a…
Abstract
Because of the importance of gastric emptying for pharmacokinetics, numerous methods have been developed for its determination. One of the methods is the salivary tracer technique, which utilizes an ice capsule containing caffeine as a salivary tracer. Despite the ice capsule’s advantage…
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Suitability of Wurster-Fluid Bed technique for functional Eudragit L-100 coating on tablet cores
Introduction
Film coating of solid dosage forms in pharmaceutical manufacturing is carried out using range of equipment, process parameters and coating formulations to achieve the quality target profile of the dosage form. Besides for aesthetic reasons, film coatings are mostly applied to modify…
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The Effect of Compression Pressure on the First Layer Surface Roughness and Delamination of…
The objectives of this study were to evaluate the delamination of convex-shaped metformin HCl (MF) and evogliptin tartrate (EG) multi-layer tablets depending on the pre-compression and main compression pressures and simultaneously correlate these results with those of a surface roughness analysis.…
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