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IFF and BASF collaborate on the Virtual Pharma Assistant Platform ZoomLab™
PRESS RELEASE
NEW YORK — Nov. 8, 2023 — IFF and BASF today announced a collaboration between the Pharma Solutions divisions of both companies, to onboard IFF’s leading product brands in pharmaceutical excipients into BASF’s Virtual Pharma Assistant platform – ZoomLab™. The platform is a…
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Evaluation of Oromucosal Natural Gum-Based Emulgels as Novel Strategy for Photodynamic Therapy of…
Photodynamic therapy (PDT) recently has been shown as a promising option in the treatment of premalignant lesions of the soft oral tissues. Effective delivery of photosensitizer is challenging due to poor drug adherence to the oromucosal epithelium. In the present work, emulgels composed of natural…
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Poly(ɛ-caprolactone) and Eudragit E blends modulate the drug release profiles from FDM printlets
Abstract
Thermoplastic polymers have been used to produce filaments by hot melt extrusion (HME), which can be applied to obtain 3D printlets by fused deposition modelling (FDM). Poly(ε-caprolactone) (PCL) is a low melting point thermoplastic polymer that provides HME filaments with excellent…
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Excipient Impact on Fenofibrate Equilibrium Solubility in Fasted and Fed Simulated Intestinal Fluids…
Solubility is a critical parameter controlling drug absorption after oral administration. For poorly soluble drugs, solubility is influenced by the complex composition of intestinal media and the influence of dosage form excipients, which can cause bioavailability and bioequivalence issues. This…
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Evaluation of a Three-Fluid Nozzle Spraying Process for Facilitating Spray Drying of Hydrophilic…
Abstract
Amorphous solid dispersions (ASDs) enable formulations to improve the solubility of poorly soluble active pharmaceutical ingredients (APIs). The amorphous state is reached through the disruption of the crystalline lattice of an API resulting in an increased apparent solubility with faster…
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Nitrite Content In Hydroxypropyl Methylcellulose
Introduction
N-nitrosamines are considered probable or possible carcinogens according to the International Agency for Research on Cancer, an agency within the World Health Organization (1).
Regulatory bodies across the world haverequested pharmaceutical companies to evaluate, investigate and…
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Guar gum as a microbially degradable component for an oral colon delivery system based on a…
Oral colon delivery has widely been pursued exploiting naturally occurring polysaccharides degraded by the resident microbiota. However, their hydrophilicity may hinder the targeting performance. The aim of the present study was to manufacture and evaluate a double-coated delivery system leveraging…
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Feasibility study of the use of a homemade direct powder extrusion printer to manufacture printed…
Among the various 3D printing techniques, FDM is the most studied in pharmaceutical research. However, it requires the fabrication of filaments with suitable mechanical properties using HME, which can be laborious and time-consuming. DPE has emerged as a single-step printing technique that can…
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The Preparation and Evaluation of Cyanocobalamin Mucoadhesive Sublingual Tablets
Cobalamin (vitamin B12), an essential vitamin with low oral bioavailability, plays a vital role in cellular functions. This research aimed to enhance the absorption of vitamin B12 using sublingual mucoadhesive tablets by increasing the residence time of the drug at the administration site. This…
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Flow behavior under shear cell analysis of two HMPC grades
Abstract
A comparative analysis was conducted to examine the flow characteristics of two HPMC grades and their fractions. Excipients processing contains critical steps in the manufacturing of solid dosage forms and therefore it is essential to determine their flowability. Flow characterization was…
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