Browsing Category
JRS Pharma
The influence of directly compressible fillers/diluents on selected compact properties and drug…
Introduction
Direct compression represents a favorable tablet manufacturing method. However, obtaining satisfactory mechanical properties of the compacts and drug dissolution remains a challenge in formulation development, particularly in the case of challenging model drugs. Rivaroxaban is…
Read More...
Read More...
Development of an Image-based Method for Tablet Microstructure Description and Its Correlation with…
The performance of a pharmaceutical formulation, such as the drug (API) release rate, is significantly influenced by the properties of the materials used, the composition of the final product and the tablet compression process parameters. However, in some cases, the knowledge of these input…
Read More...
Read More...
Comparative Study of Isomalt and Co-processed Isomalt
ABSTRACT
Objective: The study aims to compare the tableting qualities of isomalt and co-processed isomalt.
Methodology: Co-processed isomalt prepared by melt granulation method evaluated for flow property, dilution potential, Kawakita plot, consolidation index, tabletability, Heckel plot and…
Read More...
Read More...
Investigation of Dispersion Kinetics of Particulate Lubricants and their Effect on the Mechanical…
Abstract
Introduction
Tablets are commonly produced by internally adding particulate lubricants, which are known to possibly lower the mechanical strength of tablets. This reduction is caused by the coverage of matrix forming components by lubricant particles, resulting in decreased…
Read More...
Read More...
Optimization of radial extrusion and pellet coating processes using pat approaches
FDA's initiative Pharmaceutical CGMPs for the 21st century opened the door for introduction of several risk based approaches in pharmaceutical industry. One significant advancement that has emerged is the implementation of process analytical technology (PAT), which has opened doors for understanding…
Read More...
Read More...
Flow behavior under shear cell analysis of two HMPC grades
Abstract
A comparative analysis was conducted to examine the flow characteristics of two HPMC grades and their fractions. Excipients processing contains critical steps in the manufacturing of solid dosage forms and therefore it is essential to determine their flowability. Flow characterization was…
Read More...
Read More...
CPHI Barcelona 2023 – with a focus on excipients
This year CPHI Europe opens its doors in Barcelona at Fira Barcelona Gran Via.
From 24th to 26th October you can have a face-to-face chat with visitors and exhibitors again. As usual, InnoPack,
P-MEC, FDF, ICSE and BioProduction will be held together with CPHI.
Pharma Excipients gives you an…
Read More...
Read More...
Investigating the Impact of Co-processed Excipients on the Formulation of Bromhexine Hydrochloride…
Abstract
Purpose
Orodispersible tablets (orally disintegrating tablets, ODTs) have been used in pharmacotherapy for over 20 years since they overcome the problems with swallowing solid dosage forms. The successful formula manufactured by direct compression shall ensure acceptable mechanical…
Read More...
Read More...
Leveraging a multivariate approach towards enhanced development of direct compression extended…
Extended release formulations play a crucial role in the pharmaceutical industry by maintaining steady plasma levels, reducing side effects, and improving therapeutic efficiency and compliance. One commonly used method to develop extended release formulations is direct compression, which offers…
Read More...
Read More...
A Review On Novel Excipients
ABSTRACT
The field of pharmaceutical formulation is constantly evolving, driven by the need for improved drug delivery systems and enhanced therapeutic outcomes. One critical aspect of this evolution is the development and utilization of novel excipients. This review explores the types and examples…
Read More...
Read More...