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JRS Pharma
DEM analysis of the influence of stirrer design on die filling with forced powder feeding
Abstract
Die filling is a critical stage during powder compaction, which can significantly affect the product quality and efficiency. In this paper, a forced feeder is introduced attempting to improve the filling performance of a lab-scale die filling system. The die filling process is analysed…
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Comparison of properties on Orally Disintegrating Tablets (ODTs) produced by direct compression or…
Abstract
Orally disintegrating tablets (ODTs) is a popular drug delivery system as they dissolve in the mouth, usually within seconds which enables easy medication for patients with problem swallowing. In this thesis properties of ODTs were compared when produced with direct compression of the…
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Application of the Gradient boosted tree approach for thin film classification based on…
Introduction
Thin films are polymeric strips that disintegrate in the oral cavity and consist of a film-forming agent and an active pharmaceutical ingredient (API). Generally, thin films disintegrate within seconds, but their composition can be modified to allow slower disintegration and release of…
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Combination of time-dependent polymer and inulin as a coating for sustained delivery of budesonide…
Crohn's disease and ulcerative colitis, both forms of inflammatory bowel disease (IBD), are prevalent conditions. Budesonide, a medication widely recommended as a first-line treatment for Crohn's disease, necessitates the development of formulations capable of delivering the drug to the intestinal…
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Indices for the brittleness of pharmaceutical tablets: a reassessment
Brittleness is an important mechanical property. In the classical sense, a material is considered brittle if, during loading, it behaves elastically until failure. Nevertheless, it is also sometimes understood as the fact to be resistant to breakage. In the case of pharmaceutical tablets, three…
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Effect of geometrical features on the capping behavior of biconvex tablets
Abstract
Capping is a common industrial issue during the manufacturing of pharmaceutical tablets. It is influenced by both process and formulation parameters. In this work, a systematic study of the influence of the geometrical features of biconvex tablets on capping occurrence was performed on a…
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A Comparative Study on Cyclodextrin Derivatives in Improving Oral Bioavailability of Etoricoxib as a…
Etoricoxib, as a model drug, has a poor solubility and dissolution rate. Cyclodextrin derivatives can be used to solve such a problem. A comparative study was run on three cyclodextrin derivatives, namely β-CD, HP β-CD, and SBE β-CD, to solve the drug problem through the formulation of solid…
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Comparing the Performance of Raman and Near-Infrared Imaging in the Prediction of the In Vitro…
In this work, the performance of two fast chemical imaging techniques, Raman and near-infrared (NIR) imaging is compared by utilizing these methods to predict the rate of drug release from sustained-release tablets. Sustained release is provided by adding hydroxypropyl methylcellulose (HPMC), as its…
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Effect of Compaction Pressure on the Enzymatic Activity of Pancreatin in Directly Compressible…
Tableting of biomolecules is a challenging formulation phase due to their sensitivity to various process parameters, such as compression pressure, process dynamics, or the temperature generated. In the present study, pancreatin was employed as a model enzyme mixture, which was formulated in tablet…
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Design, formulation, and evaluation of risperidone mucoadhensive buccal patches
Objectives: To construct and optimize Risperidone (RIS) mucoadhesive buccal films for systemic distribution as an alternate route. To make buccal patches of Risperidone utilizing natural polymers such sodium alginate (SA), Hydroxypropyl methylcellulose (HPMC), Na CMC, and Carbopol 934 (CP 934).…
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