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JRS Pharma
Super disintegrating oromucosal nanofiber patch of zolmitriptan for rapid delivery and efficient…
Oromucosal administration of zolmitriptan using electrospun nanofiber can potentially result in blood plasma concentrations analogous to intravenous kinetics and targeting the brain due to anatomical features of the delivery site. Herein, we report the optimization of zolmitriptan and…
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Insight into the mechanism behind oral bioavailability-enhancement by nanosuspensions through…
As numerous new drug candidates are poorly water soluble, enabling formulations are needed to increase their bioavailability for oral administration. Nanoparticles are a conceptually simple, yet resource consuming strategy for increasing drug dissolution rate, as predicting in vivo oral absorption…
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Formulation development and optimization of prasugrel final dosage form by direct compression method
Abstract
Background:
Prasugrel is a member of thienopyridine class of ADP receptors that reduce the aggregation ("Clumping") of platelets by irreversibly binding to P2Y12 receptors.
Objective:
The aim of this study is to develop new formulation of Prasugrel tablets by direct compression…
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Development and Optimization of Sildenafil Orodispersible Mini-Tablets (ODMTs) for Treatment of…
The availability of age-appropriate oral dosage forms for pediatric patients has remained a challenge. Orodispersible mini-tablets (ODMTs) are a promising delivery system for pediatric patients. The purpose of this work was the development and optimization of sildenafil ODMTs as a new dosage form…
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Effect of Process Parameters, Protectants and Carrier Materials on the Survival of Yeast Cells…
The administration of living microorganisms is of special interest, with regard to probiotic microorganisms providing health benefits to the patient. Effective dosage forms require the preservation of microbial viability until administration. Storage stability can be improved by drying, and the…
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Effect of co-processed excipient type on properties of orodispersible tablets containing captopril,…
An important feature of orodispersible tablets (ODTs) is the convenient administration of the drugs, in some cases, faster onset of action, stability maintenance, and dose precision. This work focused on the preparation of ODTs containing mannitol-based co-processed excipients Prosolv® ODT G2,…
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Oligonucleotide Formulations Prepared by High-Speed Electrospinning: Maximizing Loading and…
The aim of this study was to develop antisense oligonucleotide tablet formulations using high-speed electrospinning. Hydroxypropyl-beta-cyclodextrin (HPβCD) was used as a stabilizer and as an electrospinning matrix. In order to optimize the morphology of the fibers, electrospinning of various…
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Anionic and Ampholytic High-Amylose Starch Derivatives as Excipients for Pharmaceutical and…
Many chemical modifications of starch are realized in organic (mostly methanol) phase, allowing high degrees of substitution (DS). Some of these materials are used as disintegrants. To expand the usage of starch derivative biopolymers as drug delivery system, various starch derivatives obtained in…
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Development of 3D Printed Multi-Layered Orodispersible Films with Porous Structure Applicable as a…
The direct tailoring of the size, composition, or number of layers belongs to the advantages of 3D printing employment in producing orodispersible films (ODFs) compared to the frequently utilized solvent casting method. This study aimed to produce porous ODFs as a substrate for medicated ink…
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Design and Evaluation of Sustained Release Bilayer Tablets of Oxcarbazepine
Objective
The aim of the present study is to modify the release profile of oxcarbazepine by formulating it as a bilayer tablet using direct compression method with dual compression.
Methods
In the bilayer system, the immediate release layer was formulated using four types of disintegrants, sodium…
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