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JRS Pharma
Insulin-loaded liposomes packaged in alginate hydrogels promote the oral bioavailability of insulin
Compared to subcutaneous injections, oral administration of insulin would be a preferred route of drug administration for diabetic patients. For oral delivery, both liposomes and alginate hydrogels face many challenges, including early burst release of the encapsulated drug and poor intestinal drug…
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Development and Evaluation of Novel Multi-unit Pellet System Formulation of Metoprolol Succinate for…
Abstract
Metaprolol succinate is a highly water-soluble drug with extensive first-pass metabolism. It needs to be administered about 3-4 times a day for optimum therapeutic effect. Conventional extended-release formulations are available but have their own disadvantages. The study was to designed…
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Study of different super-disintegrants and their use as a magic ingredient for different…
The time taken by the tablet to break down into fragments or granules is called disintegration. The time it takes for a batch of tablets to dissolve into particles under certain circumstances is called a disintegration test. It essentially entails an aqueous liquid penetrating the tablet, disrupting…
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Drug delivery to the targeted site of action in the human body is always affected by the excipients used and almost in the same manner by some processing variables like changes in the compression force. The aim of this study was to investigate the impact of the changes in compression forces during…
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LUBRITAB RBW – The Clean Label Lubricant for Tablet and Capsule Formulations
LUBRITAB® RBW (Rice Bran Wax) is the innovative all-natural lubricant designed to meet growing clean label demands. Derived from rice, this plant-based ingredient is gluten-free, and offers a sustainable solution for tablet and capsule formulations.
Benefits
• The only clean…
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Formulation and Evaluation of Olmesartan Medoxomil Tablets
This work proposes a methodology for the design, development, and characterization of tablets prepared by the direct compression method of olmesartan medoxomil. The main objective was to ensure a high dissolution rate of the active ingredient. Therefore, a rigorous selection of excipients was…
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Buccal films: A review of therapeutic opportunities, formulations & relevant evaluation…
The potential of the mucoadhesive film technology is hard to ignore, owing to perceived superior patient acceptability versus buccal tablets, and significant therapeutic opportunities compared to conventional oral drug delivery systems, especially for those who suffer from dysphagia. In spite of…
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Commercially Available Enteric Empty Hard Capsules, Production Technology and Application
Currently, there is a growing need to prepare small batches of enteric capsules for individual therapy or clinical evaluation since many acidic-sensitive substances should be protected from the stomach’s acidic environment, including probiotics or fecal material, in the fecal microbiota…
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Control Strategy for Excipient Variability in the Quality by Design Approach Using Statistical…
Although various quality by design (QbD) approaches have been used to establish a design space to obtain robust drug formulation and process parameters, the effect of excipient variability on the design space and drug product quality is unclear. In this study, the effect of microcrystalline…
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Preparation and Evaluation of Directly Compressible Orally Disintegrating Tablets of Cannabidiol…
This study demonstrated the implementation of a liquisolid technique to formulate directly compressible orally disintegrating tablets (ODTs). Cannabidiol (CBD), a hydrophobic cannabinoid, was prepared as a liquisolid powder using microcrystalline cellulose–colloidal silicon dioxide as a…
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