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JRS Pharma
Impact of Lubrication on Key Properties of Orodispersible Minitablets in Comparison to…
Orodispersible minitablets (ODMTs) offer several benefits like easy swallowability, dose flexibility and simple manufacturing through direct compression. In this study, the effect of lubrication on five different co-processed excipients (Ludiflash®, Parteck® ODT, Prosolv® ODT G2, galenIQ™ 721 and…
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Amorphous Solid Dispersions (ASDs): The Influence of Material Properties, Manufacturing Processes…
Abstract
Poorly water-soluble drugs pose a significant challenge to developability due to poor oral absorption leading to poor bioavailability. Several approaches exist that improve the oral absorption of such compounds by enhancing the aqueous solubility and/or dissolution rate of the drug.…
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Design of Experiments as a Tool to Optimize the Process of Coating Minitablets with Commercial…
According to the Quality by Design (QbD) concept, Design of Experiment (DoE) was used to indicate critical process parameters and optimize the fluid bed coating of minitablets in a laboratory size batch. Full factorial design was employed to increase knowledge of the process for three kinds of…
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Exploiting synergistic effects of brittle and plastic excipients in directly compressible…
Direct compression (DC) is the simplest and most economical way to produce pharmaceutical tablets. Ideally, it consists of only two steps: dry blending of a drug substance(s) with excipients followed by compressing the powder mixture into tablets. In this study, immediate-release film-coated tablets…
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Specific Excipient Requirements in Continuous Tablet Manufacturing
Abstract
Continuous Manufacturing Technology continues to gain importance in pharmaceutical manufacturing.
Although traditional processes like direct compression, roller compaction, or wet granulation are used within the continuous lines, the requirement for ingredients may differ from…
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Telmisartan Tablets Repackaged into Dose Administration Aids: Physicochemical Stability under…
Abstract
Dose administration aids (DAAs) are commonly used to assist patients with chronic disease to manage multiple medications and thus improve adherence. Several brands of telmisartan, commonly prescribed for hypertension, are available in Australia. Manufacturer’s storage advice is to leave…
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Effect of particle characteristics and foaming parameters on resulting foam quality and stability
In this study, the effects of ten different food-grade particles on bubble quality and stabilization of particle-stabilized food foams in batch and continuous foaming with and without polyglycerol ester (PGE) as an emulsifier were investigated. Particle properties, such as contact angle and…
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Preparation of stable polymer-liposome complexes by a novel approach employing a one-pot method
The purpose of this study was to prepare stable polymer-liposome complexes using a new, improved one-pot method. Complexes prepared by the conventional method were used as reference. The one-pot method combines the vesicle formation and complexation with the polymer in a single step allowing for…
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Eudragit® L100/Polyvinyl Alcohol Nanoparticles Impregnated Mucoadhesive Films as Ocular Inserts for…
The fast elimination of drugs from the cornea is one of many challenges associated with the topical administration of conventional dosage forms. The present manuscript aimed to prepare modified-release inserts containing erythromycin (ERY) to enhance drug delivery and address the aforementioned…
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Orally Dispersible Dosage Forms for Paediatric Use: Current Knowledge and Development of…
The paediatric population has always suffered from a lack of medicines tailored to their needs, especially in terms of accurate dosage, stability and acceptability. Orodispersible dosage forms have gone through a resurrection as an alternative to liquid formulations or fractioned solid formulations,…
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