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JRS Pharma
Design, characterization and in vivo performance of solid lipid nanoparticles (SLNs)-loaded…
Lornoxicam (LRX) is a potent nonsteroidal anti-inflammatory drug (NSAID) used extensively to manage pain and inflammatory conditions. However, the drug possesses poor aqueous solubility (i.e., BCS class II) and a short half-life (3–4 h). Mucoadhesive buccal tablets containing LRX -loaded solid lipid…
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Novel Esomeprazole Magnesium-Loaded Dual-Release Mini-Tablet Polycap: Formulation, Optimization,…
Esomeprazole magnesium (EMP) is a proton pump inhibitor (PPI) that reduces acid secretion. EMP has a short plasma half-life (approximately 1.3 h); hence, nocturnal acid breakthrough (NAB) frequently occurs, disturbing the patient’s nighttime comfort and sleep. We aimed to develop a novel…
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Particle Agglomeration of Acid-Modified Tapioca Starches: Characterization and Use as Direct…
Acid-modified tapioca starches (AMTSs) possessed good compressibility but showed poor particle flowability for preparing tablets by the direct compression method. The aims of this work were to prepare and characterize AMTS agglomerates using polyvinylpyrrolidone (PVP) as an agglomerating agent. The…
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Data-driven approach to mitigate quality impact of hygroscopic pharmaceutical raw materials…
The challenges of working with hygroscopic pharmaceutical raw materials can have a significant impact on the industry’s ability to make high-quality medicines. In order to mitigate the impact to the manufacturing process or product quality it is critical to understand the hygroscopicity of the raw…
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Different trends for preparation of budesonide pellets with enhanced dissolution rate
The current research attempts different approaches to overcome the poor dissolution of budesonide (a poorly water-soluble drug) from pellet formulations. Various methods such as liqui-pellet (LP) and pellets made of solid dispersion (SDP) were employed and compared to conventional pellets (CP). In…
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Review on Starter Pellets: Inert and Functional Cores
A significant proportion of pharmaceuticals are now considered multiparticulate systems. Modified-release drug delivery formulations can be designed with engineering precision, and patient-centric dosing can be accomplished relatively easily using multi-unit systems. In many cases, Multiple-Unit…
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A study on the effect of biconvex compact shape factors on prediction of dilution potential from…
Background
The purpose of this research was to compare the effect of shape factors of biconvex compacts on prediction of dilution potential from polynomial regression models of area ratio-mass fraction data of novel α-lactose monohydrate-starch orodispersible diluent (α-LSOD) and StarLac®.…
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Influence of the punch shape on the core and shell structure of press-coated tablets
Press-coated tablets are a key technology to achieve delayed releases in chronotherapeutics. The drug release properties of this kind of tablets are linked to its unique core–shell structure. It is thus important to understand the influence of the process parameters on this structure. As different…
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Material optimization for the development of delayed release formulation using computational tools
The present study involves designing a delayed-release tablet formulation of a drug belonging to BCS class-III further chemically classified as bisphosphonate to improve bioavailability. The typical approach to drug design experimentation calls for only one variable to be altered at a time, with all…
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Development of Nafamostat Mesylate Immediate-Release Tablet by Drug Repositioning Using…
We aimed to develop nafamostat mesylate immediate-release tablets for the treatment of COVID-19 through drug repositioning studies of nafamostat mesylate injection. Nafamostat mesylate is a serine protease inhibitor known to inhibit the activity of the transmembrane protease, serine 2 enzyme that…
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