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JRS Pharma
Preparation of Carbopol 934 Based Ketorolac Tromethamine Buccal Mucoadhesive Film: In Vitro, Ex…
The goal of present investigation was to formulate and evaluate ketorolac tromethamine (KTM) mucoadhesive buccal films. The films were prepared by solvent evaporation method using PVP K30, HPMC K4M, HPMC K15M, carbopol 934, chitosan, and sodium alginate as polymers and propylene glycol as…
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Study of rheological and tableting properties of lubricated mixtures of co-processed dry binders for…
Co-processed dry binders for ODTs are important multifunctional excipients for tablet manufacturing by direct compression. Testing their binary mixtures with lubricants is an important aspect of their use in combination with drugs. The aim of this study was to evaluate the rheological and…
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Investigation into the role of the polymer in enhancing microwave-induced in situ amorphization
Microwave-induced in situ amorphization is an emerging technology to tackle the persistent stability issue of amorphous solid dispersions (ASDs) during manufacture and storage. The aim of this study was to introduce new effective polymeric carriers with diverse properties to microwave-induced in…
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A Promising Single Oral Disintegrating Tablet for Co-Delivery of Pitavastatin Calcium and Lornoxicam…
Significance: Statins are an important class of drugs that help to control hyperlipidemia, and one of these statins recently used is pitavastatin calcium (PITA). Nevertheless, the most reported adverse effect of statins is myopathy. Therefore, combining statins with non-steroidal anti-inflammatory…
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The Effect of PVP Viscosity on the Binding Performance in Naproxen Tablets
Certain active ingredients can present flow and compactability challenges, requiring wet granulation to enable high-speed tableting. This study aimed to compare the performance of VIVAPHARM® PVP K25, VIVAPHARM® PVP K30, and VIVAPHARM® PVP K90 respectively as wet-granulation binders in a naproxen…
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Study of solid-state transitions and its impact on solubility and stability of Repaglinide
The aim of this research was to study the impact of melting and quenching approach on solid-state characteristics of amorphous dispersion and its impact on dissolution and solubility of Repaglinide, a BCS Class II drug. Solid dispersions of Repaglinide were prepared separately by quench cooling…
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Investigating microcrystalline cellulose crystallinity using Raman spectroscopy
Microcrystalline cellulose (MCC) is a semi-crystalline material with inherent variable crystallinity due to raw material source and variable manufacturing conditions. MCC crystallinity variability can result in downstream process variability. The aim of this study was to develop models to determine…
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The use of X-ray microtomography to investigate the microstructure of pharmaceutical tablets:…
Within this study, tablets microstructure was investigated by X-ray microtomgraphy. The aim was to gain information about their microstructure, and thus, derive deeper interpretation of tablet properties (mechanical strength, component distribution) and qualified property functions. Challenges in…
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Pharmacotechnical and Analytical Preformulation Studies for Cannabidiol Orodispersible Tablets
Obtaining orodispersible tablets (ODT) containing substances from the 2nd Biopharmaceutical Class has raised concerns as the dissolution test is challenging. This study aimed to select suitable excipients for developing orodispersible tablets containing cannabidiol (CBD) by direct compression…
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The use of X-ray microtomography to investigate the microstructure of pharmaceutical tablets:…
Within this study, tablets microstructure was investigated by X-ray microtomgraphy. The aim was to gain information about their microstructure, and thus, derive deeper interpretation of tablet properties (mechanical strength, component distribution) and qualified property functions. Challenges in…
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