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JRS Pharma
Screening pharmaceutical excipient powders for use in commercial 3D binder jetting printers
Binder jetting is an additive manufacturing technique that creates three-dimensional constructs from a powder feedstock. It is used by several industries, including pharmaceuticals. This additive approach to manufacture provides several functional benefits that are not easily achievable using…
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The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of…
The pulsatile-release Chronotopic™ system was conceived of as a drug-containing core surrounded by a coat made of swellable/soluble hydrophilic polymers, the latter being able to provide a programmable lag phase prior to drug liberation. This system was also proposed in a colon-targeting…
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Assessment of Mini-Tablets Coating Uniformity as a Function of Fluid Bed Coater Inlet Conditions
This study concerned the quality of mini-tablets’ coating uniformity obtained by either the bottom spray chamber with a classical Wurster distributor (CW) or a swirl distributor (SW). Mini-tablets with a diameter of 2.0, 2.5, and 3.0 mm were coated with hypromellose using two different inlet air…
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Developing and evaluation of orodispersible tablets containing caffeine
Starting from the premise that a reduced number of active pharmaceutical ingredients (APIs) are used to treat hypotension, the aim of this study consisted of developing new formulations of caffeine-orodispersible tablets (CAF- ODTs). The formulation variables were the type of disintegrant…
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Poster: Granfiller-D® & Hisorad® As New Co-processed Excipients For Orally Disintegrating…
Introduction: Tablets are still the most widely used dosage form for oral application due to their simple administration and relatively low manufacturing costs. One main disadvantage of tablets is the difficulty in swallowing or chewing. This is especially relevant for special patient groups, e.g.…
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Vibratory mixing of pharmaceutical powders on a single-tablet-scale
A single-tablet-scale mixing process, being part of a setup for the production of individualized tablets, is developed and studied. The process relies on the principle of vibratory mixing to achieve a homogeneous powder blend in the order of seconds. To investigate the mixing performance under…
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Formulation of sublingual promethazine hydrochloride tablets for rapid relief of motion sickness
The delivery of antihistaminic agents via the oral route is problematic, especially for elderly patients. This study aimed to develop a sublingual formulation of promethazine hydrochloride by direct compression, and to mask its intensely bitter taste. Promethazine hydrochloride (PMZ) sublingual…
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Alginates as tablet disintegrants: Understanding disintegration mechanisms and defining ranges of…
Alginates are biopolymers that have been investigated for their use in food and medical fields. Minimal information is available regarding their potential application as tablet superdisintegrants. Here we studied the disintegration action of sodium alginate (SA), calcium alginate (CA) and alginic…
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Coating characterization by hyperspectroscopy and predictive dissolution models of tablets coated…
The objective of current research was to develop the models of dissolution prediction of tablets coated with cellulose acetate (CA 320S or CA 398-10) and cellulose acetate phthalate (C-A-P) blends. Independent variables selected were coating percent (X1) and percent of CA 320S or CA 398-10 (X2) in…
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Formulate and Evaluate Famciclovir Floating Tablets
Floating drug delivery system of famciclovir was developed to prolong gastric residence time, target stomach mucosa and increase drug bioavailability by using different polymers like HPMC E15, Xanthan gum, methyl cellulose and compritol 888 ATO with different concentration. Famciclovir capable of…
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