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JRS Pharma
Using AI/ML to predict blending performance and process sensitivity for Continuous Direct…
Utilising three artificial intelligence (AI)/machine learning (ML) tools, this study explores the prediction of fill level in inclined linear blenders at steady state by mapping a wide range of bulk powder characteristics to processing parameters. Predicting fill levels enables the calculation of…
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Discriminative Dissolution Method Development Through an aQbD Approach
Using a one-factor-at-a-time approach for dissolution method and discrimination analysis can be time-consuming and may not yield the optimal and discriminative method. To address this, we have developed a two-stage workflow for the dissolution method development followed by demonstration of…
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Effect of particle size on the dispersion behavior of magnesium stearate blended with…
The majority of tablets manufactured contain lubricants to reduce friction during ejection. However, especially for plastically deforming materials, e.g., microcrystalline cellulose (MCC), the internal addition of lubricants is known to reduce tablet tensile strength. This reduction is caused by the…
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Assessing the utility of in silico tools in early drug development: The case of a pharmaceutically…
Background: Depressive disorders contribute to an excruciating global mental health burden. Recently, there has been a great shift in interest towards substances with psychedelic potential as treatment for patients with resistant forms of depression, one of these substances being psilocybin. The…
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Investigating the prilling/vibration technique to produce gastric-directed drug delivery systems for…
Prilling/vibration technique to produce oral microcapsules was explored to achieve local delivery of misoprostol (MIS), a prostaglandin E1 analogue indicated for the treatment of gastric-duodenal ulcers, at the gastric mucosa. To improve MIS chemical stability and reduce its associated systemic side…
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Solidifying Fenofibrate Nanocrystal Suspension: A Scalable Approach via Granulation Method
The pharmaceutical industry has highlighted particle-size reduction via preparing aqueous suspensions containing nano- or submicron drug particles. Owing to the risk of agglomeration and complications during the manufacturing of solid dosage forms, the problems associated with the solidification of…
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Freeze-Drying of Encapsulated Bacteriophage T4 to Obtain Shelf-Stable Dry Preparations for Oral…
Therapeutic application of bacterial viruses (phage therapy) has in recent years been rediscovered by many scientists, as a method which may potentially replace conventional antibacterial strategies. However, one of the main problems related to phage application is the stability of bacterial…
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Formulation and Characterization of Bilastine Oral Disintegrated Tablets Using Natural and Synthetic…
Bilastine (BLS) is a second-generation H1- antihistamine that is approved recently for the symptomatic treatment of chronic urticaria. The present investigation was to develop oral disintegrating tablets of BLS to produce a fast onset of action. In this study, an attempt was made to compare the…
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Effect of Croscarmellose Sodium in Sustained Release Layer of Valsartan in Bilayer Tablet with…
The aim of the study was to design and evaluate bilayer tablets of clopidogrel as immediate release and quick relief and valsartan for sustained release and check the effect of croscarmellose sodium (2%) in Carbopol for sustained release action. Bilayer tablets was prepared using direct compression…
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Predicting the hyperelastic properties of alginate-gelatin hydrogels and 3D bioprinted…
Additive manufacturing has been widely used in tissue engineering, as 3D bioprinting enables fabricating geometrically complicated replacements for different tissues and organs. It is vital that the replacement mimics the specific properties of native tissue and bears the mechanical loading under…
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