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JRS Pharma
Loss-on-Drying Prediction for a Vibrated Fluidised Bed Dryer by Means of Mass and Energy Balances
Abstract
Purpose
Continuous wet granulation and drying require an adequate process control strategy to ensure the product quality. The most important critical quality attributes of dried granules are the granule size distribution and moisture content. Process analytical technologies (PATs) are…
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pH-dependent pressure-sensitive colonic capsules for the delivery of aqueous bacterial suspensions
Microbiome-based therapies hold great promise for treating various diseases, but the efficient delivery of live bacteria to the colon remains a challenge. Furthermore, current oral formulations, such as lyophilized bacterial capsules or tablets, are produced using processes that can decrease…
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Statistical Optimization of Fast Dissolving Tablet Contains Isosorbide Dinitrate for the Treatment…
Abstract
The ultimate objective about this experiment was to create a fast-dissolving tablet Isosorbide dinitrate that released its medication quickly. The physical properties of tablets, such as hardness, angle of repose, weight variation, and friability were assessed. In-vitro release was…
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Characterizing a design space for a twin-screw wet granulation process: A case study of…
Abstract
Twin-screw wet granulation is an emerging continuous manufacturing technology for solid oral dosage forms. This technology has been successfully employed for the commercial manufacture of immediate-released tablets. However, the higher polymer content in extended-release (ER) formulations…
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Comprehensive Evaluation of Polymer Types and Ratios in Spray-Dried Dispersions: Compaction,…
Abstract
Amorphous solid dispersion (ASD) is a well-established strategy for enhancing the solubility and bioavailability of poorly soluble drugs. A significant portion of ASD products are in tablet form. However, the influence of common polymers and drug loading on the manufacturability of ASD…
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Supercritical fluid technology as a strategy for nifedipine solid dispersions formulation: in vitro…
Abstract
Supercritical fluid technology (SFT) is an insufficiently investigated approach for the production of solid dispersions, it is environmentally acceptable and has a high potential for application in the pharmaceutical industry. The aim of this work was to formulate and characterize…
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Physicochemical reports of gliclazide-carplex solid dispersions and tablets prepared with directly…
Abstract
Objectives
The main goal of this research was to develop better tablet formulations by utilizing solid dispersions (SDs) and coprocessing excipients composite to achieve a better release rate of poor water-soluble gliclazide.
Methods
The solvent evaporation method made SDs of…
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3D bioprinting of multifunctional alginate dialdehyde (ADA)–gelatin (GEL) (ADA-GEL) hydrogels…
The present work explores the 3D extrusion printing of ferulic acid (FA)-containing alginate dialdehyde (ADA)–gelatin (GEL) scaffolds with a wide spectrum of biophysical and pharmacological properties. The tailored addition of FA (≤0.2 %) increases the crosslinking between FA and GEL in the…
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Pre and post characterization of ODTs with emphasis on compression force and quality of…
Oral dispersible tablets (ODTs) are patient compliant dosage forms which rapidly disintegrate in the mouth following active absorption with rapid onset of action. The current study was designed to resolve compression problems used for ODTs, as high compression force exhibited hardness and drug…
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Enhancing Dissolution Efficiency of Ketoprofen, A Rheumatoid Arthritis Pain Management Drug, through…
This article is part of the issue: PROCEEDINGS OF THE INTERNATIONAL CONFERENCE OF THE CHINESE RHEUMATOLOGISTS (ICCR) 25–26 November 2023
Abstract
Background
Ketoprofen (KPN) is commonly prescribed drug to alleviate pain related with rheumatoid arthritis (RA).…
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