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Lipoid
Lipid-coated nanocrystals of paclitaxel as dry powder for inhalation: Characterization, in-vitro…
Abstract
Background
Nanocrystals can be produced as a dry powder for inhalation (DPIs) to deliver high doses of drug to the lungs, owing to their high payload and stability to the shear stress of aerosolization force. Furthermore, lipid-coated nanocrystals can be formulated to improve the drug…
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Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of…
Solid lipid microparticles (SLMs) represent a promising approach for drug delivery in anti-acne applications. In this study, asiatic acid-loaded SLMs (AASLMs) were prepared by melt emulsification method in conjunction with freeze-drying. Comprehensive evaluations comprised particle size, %entrapment…
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Supersaturable diacyl phospholipid dispersion for improving oral bioavailability of brick dust…
This study aims to investigate the potential use of polymer inclusion in the phospholipid-based solid dispersion approach for augmenting the biopharmaceutical performance of Aprepitant (APT). Initially, different polymers were screened using the microarray plate method to assess their ability to…
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Optimization of Hydroxypropyl Methylcellulose (HPMC) and Carbopol 940 in Clindamycin HCl Ethosomal…
Clindamycin HCl has anti-acne properties because it can inhibit the growth of Propionibacterium acnes (P. acnes) bacteria. However, the bioavailability of clindamycin HCl is less than 13% of the given dose, so it needs to be developed in the form of ethosomes to increase its bioavailability. This…
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3D-Printed Lipid Mesophases for the Treatment of Chronic Liver Disease
Abstract
Although lipid-based formulations are an attractive approach for enhancing the oral bioavailability of lipophilic drugs, their addition into solid oral dosage forms has been proven challenging due to their high viscosity and heat sensitivity. Therefore, unlike the traditional tableting…
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Surfactants for stabilization of dermal emulsions and their skin compatibility under UVA…
Phospholipids are versatile formulation compounds with high biocompatibility. However, no data on their effect on skin in combination with UVA radiation exist. Thus, it was the aim of this work to (i) develop o/w nanoemulsions (NEs) differing in surfactant type and to investigate their…
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Influence of preparation method and choice of phospholipid on co-amorphization, physical stability,…
This case study aimed to evaluate the feasibility of forming equimolar co-amorphous drug-phospholipid systems by different preparation methods. Indomethacin (IND) was chosen as a model drug and combined with three phospholipids of natural origin (soybean phosphatidylcholine (SPC), hydrogenated…
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Hypericin emulsomes combined with hollow microneedles as a non-invasive photodynamic platform for…
Rheumatoid arthritis (RA) is a joint-destructive autoimmune disease that severely affects joint function. Despite the variability of treatment protocols, all of them are associated with severe side effects that compromise patient compliance. The main aim of the current study is to prepare localized…
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Nose-to Brain Delivery of Resveratrol, a Non-Invasive Method for the Treatment of Cerebral Ischemia
Abstract
Cerebral ischemia represents a particular condition among neurological diseases due to its high frequency, high associated mortality, and the permanent disability in patients that survive it. Numerous studies in animal models have demonstrated the protective properties of resveratrol…
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Inhaled dry powder liposomal azithromycin for treatment of chronic lower respiratory tract infection
A dry powder inhaled liposomal azithromycin formulation was developed for the treatment of chronic respiratory diseases such as cystic fibrosis and bronchiectasis. Key properties including liposome size, charge and encapsulation efficiency powder size, shape, glass transition temperature (Tg), water…
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