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Lipoid
Double layer spherical Nanoparticles with Hyaluronic Acid Coating to Enhance Oral Delivery of…
Soybean phospholipid was used as an amphiphilic material to form reverse micelles (RMs) in medium glycerol monolinoleate (Maisine) with Exenatide (EXT.) encapsulated in the polar core formed by the hydrophilic part of phospholipid. Cremopher RH40 and caprylocaproyl macrogol-8 glycerides…
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Hydrogenated phospholipid, a promising excipient in amorphous solid dispersions of fenofibrate for…
Amorphous solid dispersions (ASD) represent a viable formulation strategy to improve dissolution and bioavailability of poorly soluble drugs. Our study aimed to evaluate the feasibility and potential role of hydrogenated phospholipid (HPL) as a matrix material and solubilizing additive for binary…
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Topical delivery systems containing clotrimazole for the management of candidiasis: effect of…
WHO classified Candida albicans as one of the four critical priority fungi for public health worldwide in 2022. Conventional topical formulations commercially available for the treatment of cutaneous candidiasis are associated with low drug bioavailability at the infection site and the lack of a…
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Protein corona formation on lipidic nanocapsules: Influence of the interfacial PEG repartition
The parameters currently used for characterization of nanoparticles, such as size and zeta potential, were not able to reflect the performance of a nanocarrier in the biological environment. Therefore, more thorough in vitro characterization is required to predict their behavior in vivo, where…
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Effects of Phospholipid Structure on the Acoustic Cavitation of Functionalized Mesoporous Silica…
This study investigates the acoustic response of phospholipid-coated, hydrophobically modifed mesoporous silica nanoparticles (PL-HMSNs) for image-guided drug delivery. PL-HMSNs were first stabilized with a PEGylated lipid, DSPE-PEG2k-methoxy, and the efect of particle concentration on the…
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Inhalable dry powder containing lipid polymer hybrid nanoparticles of Nintedanib esylate: In vitro…
The key objective of this research work was to develop and evaluate dry powder for inhalation containing lipid polymer hybrid nanoparticles (LPHNPs) loaded with Nintedanib esylate (NE) to target deep lung for the treatment of idiopathic pulmonary fibrosis (IPF). NE loaded LPHNPs (NE-LPHNPs) were…
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Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines
Ever since the development of the first vaccine, vaccination has had the great impact on global health, leading to the decrease in the burden of numerous infectious diseases. However, there is a constant need to improve existing vaccines and develop new vaccination strategies and vaccine platforms…
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Development and in vivo evaluation of nanoemulsions for oral delivery of low molecular weight…
Abstract
Aim
The aim of this study was the development and in vivo evaluation of different types of nanoemulsions for oral delivery of low molecular weight heparin (LMWH).
Methods
Nanoemulsions (NE) were developed consisting of mainly non-digestible components and variations of polyglycerol-,…
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Formulation of benznidazole-lipid nanocapsules: Drug release, permeability, biocompatibility, and…
Benznidazole, a poorly soluble in water drug, is the first-line medication for the treatment of Chagas disease, but long treatment periods at high dosages cause several adverse effects with insufficient activity in the chronic phase. According to these facts, there is a serious need for novel…
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Ocular permeability, intraocular biodistribution of lipid nanocapsule formulation intended for…
Recently, cGMP analogues have been investigated for the treatment of inherited retinal degenerations (IRD) using intravitreal injections. However, higher vitreous elimination rates limit the possibility to treat the retina with small molecule drugs. Here, we investigated the potential of lipid…
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