Browsing Category
Lubrizol
Formulation and in-vitro evaluation of Bosewellia Serrata extract loaded transferosomal gel for…
Objective:
The main objective of the current research work was to formulate and evaluate Bosewellia serrata extract loaded transferosomal topical gels. To overcome the drawbacks associated with oral administration of Bosewellia serrata extract in Osteoarthritis treatment.
Methodology:…
Read More...
Read More...
Development of mucoadhesive carrier systems for flavoring agents and cannabidiol
The buccal mucosa represents an attractive site to realize both local and systemic effects. It is easily accessible and transbuccal drug delivery offers the opportunity to increase bioavailability of drugs by avoiding first-pass metabolism and intestinal drug degradation. But despite numerous…
Read More...
Read More...
Optimization of the Micellar-Based In Situ Gelling Systems Posaconazole with Quality by Design (QbD)…
Background: Fungal ocular infections can cause serious consequences, despite their low incidence. It has been reported that Posaconazole (PSC) is used in the treatment of fungal infections in different ocular tissues by diluting the oral suspension, and successful results were obtained despite low…
Read More...
Read More...
Apinovex™ Polymers – Solubility-Enhancing Excipients for Amorphous Solid Dispersions
Lubrizol’s Apinovex™ polymers are high molecular weight polyacrylic acid excipients designed to provide both processing and formulation benefits for spray-dried amorphous solid dispersions (ASDs).
Apinovex polymers enable formulators to enhance the solubility of BCS Class II and IV APIs and…
Read More...
Read More...
Bilayer Buccal Tablets of Furosemide: Design and Evaluation
Aim: In the present study, mucoadhesive bilayer buccal tablets of furosemide were fabricated with the objective of avoiding first-pass metabolism and enhancing the bioavailability along with reducing the dosing frequency.
Methodology: Direct compression method was used to prepare bilayer buccal…
Read More...
Read More...
Resveratrol-Loaded Vesicular Elastic Nanocarriers Gel in Imiquimod-Induced Psoriasis Treatment: In…
This work aimed to develop a new efficient approach for safe treatment of psoriasis. To achieve that, resveratrol-loaded spanlastics (F1-F12) were prepared and evaluated by complete in vitro characterization. The two optimal formulations (F10 and F11) had their particle size in the nano range with…
Read More...
Read More...
Formulating for the Future: Oral Drug Delivery for Improving Bioavailability & Patient Outcomes
Oral drug administration is critical for the delivery of drugs in various therapeutic areas, such as cardiovascular and pain management. It is considered the preferred route of administration due to its significant advantages, including being both painless and convenient. The importance of oral drug…
Read More...
Read More...
Quantitative Structure-Activity Relationship of Enhancers of Licochalcone A and Glabridin Release…
This study aimed to systematically compare licochalcone A (LicA) and glabridin (Gla) (whitening agents) release and permeation from Carbomer 940 (CP) hydrogels with different enhancers, and evaluate the relationship between the quantitative enhancement efficacy and structures of the enhancers. An in…
Read More...
Read More...
Concept of Orodispersible or Mucoadhesive “Tandem Films” and Their Pharmaceutical Realization
Orodispersible or mucoadhesive films as a patient-oriented dosage form for low-dosed drugs are usually produced using solvent casting. This paper presents a modification of the solvent casting technique that aimed to divide oral films into two or more compartments.
The proposed objectives and…
Read More...
Read More...
The Effect of Polymers on Drug Release Kinetics in Nanoemulsion In Situ Gel Formulation
Glaucoma is an ocular condition characterized by elevated intraocular pressure (IOP). Conventional treatments of glaucoma face poor corneal permeability and bioavailability. To address these issues, a nanoemulsion in situ gel of Timolol maleate was developed in this study by adding the polymer…
Read More...
Read More...