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Lubrizol
Apinovex™ Polymers – the Key to Addressing Solubility Challenges in Oral Formulations
Between 40-70% of marketed drugs and up to 90% of all new chemical entities (NCEs) suffer from poor water solubility, meaning they don’t readily dissolve in an aqueous solution. This has significant negative consequences for the bioavailability of the active pharmaceutical ingredient (API), with an…
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Formulation of Lipid-Based Tableted Spray-Congealed Microparticles for Sustained Release of…
Spray-congealing (SPC) technology was utilized to prepare lipid-based microparticles (MP) capable of sustaining the release of Vildagliptin (VG) for use as a once-daily treatment for type 2 diabetes mellitus. VG microparticles were prepared using Compritol®and Gelucire®50/13 as lipid carriers in the…
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Cyclodextrin as Functional Carrier in Development of Mucoadhesive Tablets Containing Polygoni…
Polygoni cuspidati root is a resveratrol-rich source with anti-inflammatory, angiogenic and neuroprotective effects. The raw material was standardized for the content of resveratrol, for which there is a special justification for administration within the oral mucosa. To improve the solubility of…
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Emulgel Approach to Formulation Development: A Review
Topical drug delivery is the delivery of drugs anywhere in the body through skin, vaginal, ophthalmic and rectal routes. Drugs may be given for localized or systemic effects. Topical formulations with varying physicochemical properties, such as solid, semisolid, or liquid, can be developed. The…
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Development and characterization of multiparticulate system as an alternative to unit dosage forms…
Background
Currently, the Bilayer tablets, Tablet in tablet and Inlay tablets composed of Glimepiride (GMP) and Pioglitazone (PGH) as immediate release part, and Metformin (MFH) as sustained-release part are available for the treatment of type II diabetes mellitus (T2DM). In these products, there…
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QbD steered fabrication of Pullulan-Terminalia catappa-Carbopol®971P film forming gel for improved…
In present work, a film forming gel (FFG) was developed through ingenious amalgamation of polymers: Pullulan, Terminalia catappa and Carbopol®971P ® for cutaneous delivery of clotrimazole (CTZ) employing D-optimal mixture design. The developed FFG possess pseudoplastic, viscoelastic, thixotropic…
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Droplet splashing during the impact on liquid pools of shear-thinning fluids with yield stress
The impact of droplets on liquid pools is ubiquitous in nature and many industrial applications. Most previous studies of droplet impact focus on Newtonian fluids, while less attention has been paid to the impact dynamics of non-Newtonian droplets, even though non-Newtonian fluids are widely used in…
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Formulation, Optimization and Evaluation of Luteolin-Loaded Topical Nanoparticulate Delivery System…
In the present study, luteolin (LT)-loaded nanosized vesicles (LT-NVs) were prepared by a solvent evaporation–hydration method using phospholipid and edge activator. The formulation was optimized using three factors at a three-level Box–Behnken design. The formulated LT-NVs were prepared using the…
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Manufacturing and Examination of Vaginal Drug Delivery System by FDM 3D Printing
Vaginal drug delivery systems can provide a long-term and constant liberation of the active pharmaceutical ingredient even for months. For our experiment, FDM 3D printing was used to manufacture the vaginal ring samples from thermoplastic polyurethane filament, which enables fast manufacturing of…
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How to Tame Recalcitrant Ingredients with Technological Processes
Among the currently trending functional ingredients, interest in natural sources such as turmeric and its polyphenol, curcumin, has been increasing for years. The spice is not only in demand in the culinary world, but has also found great promise in both consumer and scientific applications.1 …
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