Browsing Category
Lubrizol
Towards a better understanding of thermally treated polycarbophil matrix tablets for controlled…
Polycarbophil (POL), a polyacrylic acid cross-linked with divinyl glycol, is widely used in semisolid and solid dosage forms. When undergoing a thermal treatment in the range 120–160 °C, POL shows interesting morphological modifications, related to changes in physical properties, such as swelling of…
Read More...
Read More...
Preparation of Carbopol 934 Based Ketorolac Tromethamine Buccal Mucoadhesive Film: In Vitro, Ex…
The goal of present investigation was to formulate and evaluate ketorolac tromethamine (KTM) mucoadhesive buccal films. The films were prepared by solvent evaporation method using PVP K30, HPMC K4M, HPMC K15M, carbopol 934, chitosan, and sodium alginate as polymers and propylene glycol as…
Read More...
Read More...
Gastroretentive Technologies in Tandem with Controlled-Release Strategies: A Potent Answer to Oral…
There have been many efforts to improve oral drug bioavailability and therapeutic efficacy and patient compliance. A variety of controlled-release oral delivery systems have been developed to meet these needs. Gastroretentive drug delivery technologies have the potential to achieve retention of the…
Read More...
Read More...
The interactions in ternary system made of xanthan gum, Carbopol 940 and anionic/nonionic surfactant
The development and optimization of systems consist of polymers and surfactants are strongly related to the presence of interactions between them. Therefore, the interpolymer complexes between biopolymer xanthan gum and synthetic polymer Carbopol 940 were investigated before and after the addition…
Read More...
Read More...
Analysis of Endoscopic Injectability and Post-Ejection Dripping of Yield Stress Fluids: Laponite,…
Yield stress fluids, which show reversible gel–sol transition and a decrease in viscosity via shear, are expected for endoscopic applications. However, quantitative analyses of such fluids, including pressure drop during endoscopic catheter delivery and post-delivery dripping, have not yet been…
Read More...
Read More...
Preliminary study for the development of potent hydrogels for local drug delivery applications
Currently, design and development of formulations for the oral cavity and local application is a rather challenging process since the components should be non-irritant and provide relief. Hydrogels-based drug delivery systems have been proposed as suitable candidates for oral mucosal (eg, buccal,…
Read More...
Read More...
Quercetin loaded silver nanoparticles in hydrogel matrices for diabetic wound healing
Quercetin (QCT) is an effective antioxidant, antifibrotic and wound healing agent. Silver nanoparticles (AgNPs) are an effective antimicrobial and wound healing agent and considered as gold standard for wound treatment especially diabetic and burn wounds. The present study aimed to investigate QCT…
Read More...
Read More...
Tacrolimus Encapsulated Mesoporous Silica Nanoparticles Embedded Hydrogel for the Treatment of…
Atopic dermatitis (AD) is a repetitive inflammatory skin disorder with limited treatment options. Innovative targeted therapies are gaining significant interest and momentum towards disease control including better ways to deliver drugs topically. Tacrolimus is one such compound which is used to…
Read More...
Read More...
Formulation development and in-vitro evaluation of dexlansoprazole loaded double walled microspheres
In the present work, double walled microspheres of Dexlansoprazole using Sodium alginate, HPMC E15, Xanthan gum, Ethyl cellulose as copolymers and along with Carbopol were formulated to deliver Dexlansoprazole through oral route. Details regarding the preparation and evaluation of the formulations…
Read More...
Read More...
Solving Bioavailability Challenges Using A Molecule’s Target Product Profile (TPP)
What is the Target Product Profile (TPP)?
The Target Product Profile (TPP) describes the desired characteristics of the proposed drug product aimed at a particular disease. We consider the TPP to be a living document that may change as together we learn more about your molecule. The TPP will…
Read More...
Read More...