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Lubrizol
Comparison between polymeric excipients using SeDeM expert system in combination with mathematical…
Based on the quality by design approach, we used the SeDeM expert system to assess seven polymers of different chemical nature and molecular weight for their use in direct compression. Because the SeDeM system fails by not evaluating the mechanical properties of materials, we used the Heckel and…
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Solving parenteral solubility challenges in the development of oncology therapeutics
It’s no secret that solubility and bioavailability issues continue to challenge formulators and drug developers. Approximately 60-90% of potential new active pharmaceutical ingredients (APIs) in development pipelines, and more than 40% of those in reformulation, are poorly water-soluble. (1) Due to…
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Advanced multifunctional nano-lipid carrier loaded gel for targeted delivery of 5-flurouracil and…
Non-melanoma skin cancer is one of the most common malignancies reported around the globe. Current treatment therapies fail to meet the desired therapeutic efficacy due to high degree of drug resistance. Thus, there is prominent demand in advancing the current conventional therapy to achieve desired…
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Lubrizol Licenses Award-Winning Apisolex™ Excipient to Welton Pharma to Develop a Novel Cancer…
Upwards of 60% of Cancer Drugs Have Solubility Issues, Lubrizol and Welton Aim to Address This Challenge
CLEVELAND, Ohio – June 21, 2023 – The Lubrizol Corporation announces the licensing of its novel excipient polymer technology, Apisolex™ excipient, to Welton Pharma (Welton). The license allows…
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Chitosan coated niosomes for nose-to-brain delivery of clonazepam: formulation, stability and…
Crossing the Blood Brain Barrier constitutes a challenge in drug administration to the brain. In this context, nose-to-brain delivery is explored as an alternative route in the treatment of central nervous system disorders, and nanotechnology constitutes a promising tool for drug delivery to the…
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Development and preclinical assessment of nanoemulgel loaded with phytoconstituents for the…
In recent years, natural ingredients have gained importance for therapeutic treatment due to their minimal toxicity. However, the delivery of these phytoconstituents poses a challenge to provide better efficacy. Current research reports the development of nanoemulgel (NEG) loaded with ginger…
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Hot-melt extruded in situ gelling systems (MeltDrops Technology): Formulation development, in silico…
In situ gelling systems (ISGS) can prolong retention time and bioavailability of ophthalmic solutions. The complexity and cost of ISGS avert their industrial scale-up and clinical implementation. In this study, we demonstrate novel application of hot-melt extrusion (HME) technology for continuous…
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Emulsion-Based Gel Loaded with Ibuprofen and Its Derivatives
The aim of this study was to evaluate the effect of vehicle and chemical modifications of the structure of active compounds on the skin permeation and accumulation of ibuprofen (IBU). As a result, semi-solid formulations in the form of an emulsion-based gel loaded with ibuprofen and its derivatives,…
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Technological Aspects and Evaluation Methods for Polymer Matrices as Dental Drug Carriers
he development of polymer matrices as dental drug carriers takes into account the following technological aspects of the developed formulations: the composition and the technology used to manufacture them, which affect the properties of the carriers, as well as the testing methods for assessing…
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Nanostructured Lipid Carrier–Based Gel for Repurposing Simvastatin in Localized Treatment of Breast…
Simvastatin (SMV) is noticed as a repurposed candidate to be effective against breast cancer (BC). However, poor solubility, dose-limiting toxicities, and side effects are critical hurdles in its use against BC. The above drawbacks necessitate the site-specific (localized) delivery of SMV via …
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