Browsing Category
Lubrizol
Development and Characterization of the Floating Beads Containing the BCS Class II Drug Lumafentrine…
Floating Drug delivery systems are designed to prolong the gastric residence time after oral administration. Gastroretentive systems can remain in the gastric region for several hours and significantly prolong the gastric residence of the drugs. Prolonged gastric retention improves bioavailability,…
Read More...
Read More...
In Vitro and In Vivo Characterization of the Transdermal Gel Formulation of Desloratadine for…
Chronic use of antihistamines can induce abnormalities in lipid absorption with potential excessive accumulation of lipids in the mesentery that can lead to the development of obesity and a metabolic syndrome. The focus of the present work was to develop a transdermal gel formulation of…
Read More...
Read More...
Inclusion Complex of Ibuprofen-β-Cyclodextrin Incorporated in Gel for Mucosal Delivery: Optimization…
β-Cyclodextrin/ibuprofen inclusion complex was synthesized by freeze-drying method and characterized for phase solubility profiles, infrared spectra, thermal analysis, and X-ray powder diffractograms. The inclusion complex with HP-β-CD, as confirmed by molecular dynamics simulations, enhanced the…
Read More...
Read More...
Development, QbD based optimization and in vitro characterization of Diacerein loaded nanostructured…
Abstract
Objective
DCN is a chondro-protective agent which displays inadequate oral bioavailability along with gastrointestinal side effects. It is a choice of drug for treatment of osteoarthritis. Therefore, the objective of this study was to develop and optimize DCN loaded nanostructured lipid…
Read More...
Read More...
Assessing and Predicting Physical Stability of Emulsion-Based Topical Semisolid Products: A Review
The emulsion-based topical semisolid dosage forms present a high degree of complexity due to their microstructures which is apparent from their compositions comprising at least two immiscible liquid phases, often times of high viscosity. These complex microstructures are thermodynamically unstable,…
Read More...
Read More...
The development of a solid lipid nanoparticle (SLN)-based lacticin 3147 hydrogel for the treatment…
Chronic wounds affect millions of people globally. This number is set to rise with the increasing incidence of antimicrobial-resistant bacterial infections, such as methicillin-resistant Staphylococcus aureus (MRSA), which impair the healing of chronic wounds. Lacticin 3147 is a two-peptide chain…
Read More...
Read More...
Enhancement of in-vitro anti-oral cancer activities of silymarin using dispersion of nanostructured…
Silymarin (SME) shows multiple therapeutic actions against several cancers, however, low aqueous solubility and poor bioavailability issues restrict its clinical use. In this study, SME was loaded in nanostructured lipid carriers (NLCs) and further incorporated in mucoadhesive in-situ gel…
Read More...
Read More...
Mucoadhesive Oro-Gel–Containing Chitosan Lipidic Nanoparticles for the Management of Oral Squamous…
Abstract
Purpose
The aim of this research work was to develop a mucoadhesive oro-gel–containing resveratrol loaded folate conjugated chitosan-lipidic nanoparticles (RES-FA-LP-NPs) for targeted delivery to oral squamous cell carcinoma (OSCC).
Method
RES-FA-LP-NPs were prepared by hot…
Read More...
Read More...
High Drug Loaded Pellets produced by ProCell® Technology
Poster presented at 4th European Conference on Pharmaceutics 20-21 March 2023 | Marseille, France:
Drug loaded pellets were produced by using the ProCell® lab system technology. The aim was to produce highly drug loaded matrix pellets with an API-polymer ratio of approximately 95:5 by using…
Read More...
Read More...
Preparation, Characterization and Evaluation of Flavonolignan Silymarin Effervescent Floating Matrix…
The convenient and highly compliant route for the delivery of active pharmaceutical ingredients is the tablet. A versatile platform of tablets is available for the delivery of therapeutic agents to the gastrointestinal tract. This study aimed to prepare gastro retentive drug delivery floating…
Read More...
Read More...