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Merck
Poly(ɛ-caprolactone) and Eudragit E blends modulate the drug release profiles from FDM printlets
Abstract
Thermoplastic polymers have been used to produce filaments by hot melt extrusion (HME), which can be applied to obtain 3D printlets by fused deposition modelling (FDM). Poly(ε-caprolactone) (PCL) is a low melting point thermoplastic polymer that provides HME filaments with excellent…
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In vivo pharmacodynamics of lactoferrin-coupled lipid nanocarriers for lung carcinoma: intravenous…
Lung carcinoma characterized by high mortality rate and poor prognosis; the efficacy of drug delivery should improve drug exposure at the targeted site. This study aims at evaluating lactoferrin role as targeting ligand besides the administration route impact on tissue deposition and organ…
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Evaluation of a Three-Fluid Nozzle Spraying Process for Facilitating Spray Drying of Hydrophilic…
Abstract
Amorphous solid dispersions (ASDs) enable formulations to improve the solubility of poorly soluble active pharmaceutical ingredients (APIs). The amorphous state is reached through the disruption of the crystalline lattice of an API resulting in an increased apparent solubility with faster…
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The Anti-Oxidant Curcumin Solubilized as Oil-in-Water Nanoemulsions or Chitosan Nanocapsules…
Abstract
The bacterium Helicobacter pylori (H. pylori) represents a major risk factor associated with the development of gastric cancer. The anti-oxidant curcumin has been ascribed many benefits to human health, including bactericidal effects. However, these effects are poorly reproducible because…
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Improving API Solubility – by Merck
Overview of the article
The Importance of API Solubility for Solid and Liquid Dosage Forms
The Solubilization Process
The Biopharmaceutics Classification System of APIs
The Developability Classification System
The Central Role of Solubility and Permeability for API Absorption…
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Use of Excipients in Downstream Processing to Improve Protein Purification
Excipients are used to improve the stability of protein-based therapeutics by protecting the protein against a range of stress conditions such as temperature changes, pH changes, or agitation. Similar stresses are applied to proteins during downstream purification. Shifts in pH during Protein A…
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Challenges in the Transfer and Scale-Up of Mini-Tableting: Case Study with Losartan Potassium
Mini-tablets (MTs) with losartan potassium were developed to treat the rare disease Epidermolysis Bullosa. The focus was placed on transfer and scale-up of a direct compressible formulation from the compaction simulator STYL’One Evo (CS) to the rotary tablet press Korsch XM 12 (RP). Transfer of…
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Formulation and in vitro evaluation of pramipexole orally disintegrating tablets for pediatric…
Abstract
In this study, orally disintegrating tablets (ODT) of pramipexole dihydrochloride monohydrate (PPX) was developed with direct compression method by using ready-to-use excipients Parteck® ODT, Pharmaburst® 500, Ludiflash®, F Melt®, and Prosolv® Easytab SP for pediatric restless leg syndrome…
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The influence of directly compressible fillers/diluents on selected compact properties and drug…
Introduction
Direct compression represents a favorable tablet manufacturing method. However, obtaining satisfactory mechanical properties of the compacts and drug dissolution remains a challenge in formulation development, particularly in the case of challenging model drugs. Rivaroxaban is…
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The Preparation and Evaluation of Cyanocobalamin Mucoadhesive Sublingual Tablets
Cobalamin (vitamin B12), an essential vitamin with low oral bioavailability, plays a vital role in cellular functions. This research aimed to enhance the absorption of vitamin B12 using sublingual mucoadhesive tablets by increasing the residence time of the drug at the administration site. This…
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