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Merck
Advanced process automation of a pharmaceutical continuous wet granulation line: Perspectives on the…
Abstract
Pharmaceutical continuous manufacturing provides the appropriate tools (e.g. the understanding of process dynamics and appropriate and adaptable control strategy) in order to deal with Quality-by-Design expectations and even to the future smart manufacturing described by…
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Evaluation of the Effects of Storage Conditions on Spray-Dried siRNA-LNPs Before and after…
In an ideal world, pharmaceutical drugs would have infinite shelf life, no susceptibility to degradation, chemical reactions or loss of efficacy. In reality, these processes occur, however, making it desirable to extend a drugs’ shelf life. Nucleic acid-based drugs are most commonly stored as…
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Screening and optimization of supercritical fluid process for the preparation of albendazole solid…
Solid dispersion (SD) technology has been proved to be one of the most successful techniques to enhance aqueous solubility of poorly-water soluble drugs. Supercritical fluid (SCF) using carbon dioxide (CO2) became attractive due to its own advantages, including non-toxic, low temperature required,…
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Functional and Tableting Properties of Alkali-Isolated and Phosphorylated Barnyard Millet…
The functional and tableting properties of barnyard millet starch (Echinochloa esculenta) were investigated in its native (alkali-treated) and chemically modified (phosphorylated) states. The grains were pulverized, soaked, and ground before filtration to separate starch and protein. Multiple NaOH…
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Enhanced stability and skin permeation of ibuprofen-loaded solid lipid nanoparticles based binary…
Hypothesis
The type of emulsifier selected has an impact on the physicochemical properties of solid lipid nanoparticles (SLNs). This study was designed to compare the effects of emulsifiers on the physicochemical properties and in vitro skin performance of SLNs prepared from a binary mixture of…
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Topical delivery systems containing clotrimazole for the management of candidiasis: effect of…
WHO classified Candida albicans as one of the four critical priority fungi for public health worldwide in 2022. Conventional topical formulations commercially available for the treatment of cutaneous candidiasis are associated with low drug bioavailability at the infection site and the lack of a…
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Protein corona formation on lipidic nanocapsules: Influence of the interfacial PEG repartition
The parameters currently used for characterization of nanoparticles, such as size and zeta potential, were not able to reflect the performance of a nanocarrier in the biological environment. Therefore, more thorough in vitro characterization is required to predict their behavior in vivo, where…
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Impact of polymer chemistry on critical quality attributes of selective laser sintering 3D printed…
The aim of this study is to investigate the influence of polymer chemistry on the properties of oral dosage forms produced using selective laser sintering (SLS). The dosage forms were printed using different grades of polyvinyl alcohol or copovidone in combination with indomethacin as the active…
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Effect of process parameters in high shear granulation on characteristics of a novel co-processed…
In this study, insights into the development and optimization of a co-processed excipient based on mesoporous silica are presented. The main advantage of such a material is that it is appropriate for direct tablet compression and has a sufficiently large specific surface area to be suitable for…
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Development of an immediate release excipient composition for 3D printing via direct powder…
3D printing offers the possibility to prepare personalized tablets on demand, making it an intriguing technology for hospital pharmacies. For the implementation of 3D-printed tablets into the digital Closed Loop Medication Management system, the required tablet formulation and development of the…
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