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Merck
Nanocellulose-Based Film-Forming Hydrogels for Improved Outcomes in Atopic Skin
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by impaired skin barrier function. Amongst the various dermal formulations that are being used and/or investigated for AD treatment, one of the advanced approaches is the use of hydrogels as film-forming systems that are…
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Not the Usual Suspects: Alternative Surfactants for Biopharmaceuticals
Therapeutically relevant proteins naturally adsorb to interfaces, causing aggregation which in turn potentially leads to numerous adverse consequences such as loss of activity or unwanted immunogenic reactions. Surfactants are ubiquitously used in biotherapeutics drug development to oppose…
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Synergistic stabilization of emulsion gel by nanoparticles and surfactant enables 3D printing of…
Pharmaceutical formulation of oral dosage forms is continuously challenged by the low solubility of new drug candidates. Pickering emulsions, emulsions stabilized with solid particles, are a promising alternative to surfactants for developing long-term stable emulsions that can be tailored for…
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In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices
The in-situ formation of nanoparticles from polymer-based solid medicines, although previously described, has been overlooked despite its potential to interfere with oral drug bioavailability. Such polymeric pharmaceuticals are becoming increasingly common on the market and can become even more…
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Integrated in vitro – In vivo – In silico studies in the pharmaceutical development of propranolol…
In order to exploit the advantage of drug delivery through the buccal mucosa, mucoadhesive buccal films with propranolol hydrochloride based on polyethylene oxide, hydroxypropyl methylcellulose, and polyvinyl alcohol have been developed. The aim of this study was the development,…
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Nanoparticulate impurities in the pharmaceutical excipient trehalose induce an early immune response
Abstract
Background
Pharmaceutical excipients are an important part of biological products. However, few attempts have been made to distinguish between the risk of inflammation associated with the biological products themselves and that associated with excipients. The analysis of early immune…
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Comparison of the Behavior of 3D-Printed Endothelial Cells in Different Bioinks
Biomaterials with characteristics similar to extracellular matrix and with suitable bioprinting properties are essential for vascular tissue engineering. In search for suitable biomaterials, this study investigated the three hydrogels alginate/hyaluronic acid/gelatin (Alg/HA/Gel), pre-crosslinked…
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Enhancing the Solubility of Active Pharmaceutical Ingredients Using Hot Melt Extrusion and Polyvinyl…
Solubility of the active pharmaceutical ingredient (API) in an oral formulation is critical for absorption from the gastrointestinal (GI) tract and the intended therapeutic effect. Ensuring that an API has the necessary solubility can be challenging for drug developers and formulators. If…
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A Comprehensive Scientific Survey of Excipients Used in Currently Marketed, Therapeutic Biological…
Purpose
The steady development of biotechnology-derived therapeutic biologics over the last few decades has generated drugs that are now standard medical treatments for a range of indications. While the development of protein products has surged in recent years, the formulation and delivery of…
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Brain nanotargeted [131I] I-Rolapitant as a model for brain imaging: Intranasal formulation,…
The goal of this study was to create a novel single-photon emission computed tomography (SPECT) probe that would enable the visualization of neurokinin-1 NK1 receptor systems in the brain for the precise diagnosis and follow-up of many brain-related disorders. Rolapitant (RT), a selective,…
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