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Merck
Determination of Mucoadhesion of Polyvinyl Alcohol Films to Human Intestinal Tissue
Abstract
The absorption of drugs with narrow absorption windows in the upper small intestine can be improved with a mucoadhesive drug delivery system such as enteric films. To predict the mucoadhesive behaviour in vivo, suitable in vitro or ex vivo methods can be performed. In this study, the…
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Parteck® MXP Excipient – Mix. Melt. Perform.
Parteck® MXP Excipient
The hot melt extrusion difference
Poor solubility of APIs is a critical challenge in drug development. One formulation technique to increase solubility and, consequently, improve bioavailability of drugs is hot melt extrusion (HME). With this technology, the API is…
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Microneedle array patches for sustained delivery of fluphenazine: A micron scale approach for the…
Schizophrenia is a severe chronic mental illness characterised by impaired emotional and cognitive functioning. To treat this condition, antipsychotics are available in limited dosage forms, mainly oral and injectable formulations. Although injectable antipsychotics were designed to enhance…
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Integrated continuous melt granulation-based powder-to-tablet line: process investigation and…
In the last decades, continuous manufacturing (CM) has become a research priority in the pharmaceutical industry. However, significantly fewer scientific researches address the investigation of integrated, continuous systems, a field that needs further exploration to facilitate the implementation of…
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3D printing tablets for high-precision dose titration of caffeine
Through 3D printing (3DP), many parameters of solid oral dosage forms can be customised, allowing for truly personalised medicine in a way that traditional pharmaceutical manufacturing would struggle to achieve. One of the many options for customisation involves dose titration, allowing for gradual…
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Development of an ethanol-free salbutamol sulfate metered-dose inhaler: Application of molecular…
Abstract
Introduction
More than fifty years after the commercialization of the Ventolin metered-dose inhaler (MDI), its constituent active ingredient, salbutamol sulfate (SS), remains the most prescribed short-acting beta agonist for the first-line treatment of acute asthma attacks and the…
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Regulatory Considerations for Excipients used in Lipid Nanoparticles
Lipid excipients and delivery systems such as lipid nanoparticles (LNPs) are essential for a wide variety of therapeutics including chemotherapy, analgesics, gene therapy, respiratory and ocular applications, anti-fungal applications, and vaccines (see Figure 2).1 In many cases, these excipients…
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Pullulan/Poly(vinyl alcohol) Hydrogels Loaded with Calendula officinalis Extract: Design and In…
The therapeutic efficiency of plant extracts has been limited by their poor pharmaceutical availability. Hydrogels have promising potential to be applied as wound dressings due to their high capacity to absorb exudates and their enhanced performance in loading and releasing plant extracts. In this…
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Polyvinyl alcohol: Revival of a long lost polymer
Introduction
With target-oriented drug discovery and an increasing focus on specialized medicines, the manufacturing of final drug products is becoming more and more complex. The processing and formulation of active pharmaceutical ingredients (APIs) designed with a specific target and functionality…
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In vitro-in vivo relationship for amorphous solid dispersions using a double membrane…
The use of amorphous solid dispersions (ASDs) is one commonly applied formulation strategy to improve the oral bioavailability of poorly water-soluble drugs by overcoming dissolution rate and/or solubility limitations. While bioavailability enhancement of ASDs is well documented, it has often been a…
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