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Merck
Specific surface area of mannitol rather than particle size dominant the dissolution rate of poorly…
The dissolution behavior of tablets, particularly those containing poorly water-soluble drugs, is a critical factor in determining their absorption and therapeutic efficacy. Traditionally, the particle size of excipients has been considered a key property affecting tablet dissolution. However,…
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Formulating pharmaceutical topical dosage forms with high level of solvents and minimal quantity of…
Poster presented by Gattefosse and RCPE at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical (PBP) Technology, 18 - 21 March 2024, Vienna, Austria:
INTRODUCTION
Some APIs are very challenging to formulate. This is the case for example when the drug has limited…
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Optimizing Bioavailability and Antihypertensive Activity of Carvedilol Cubosomes using D-Optimal…
Abstract
Carvedilol (CARV) -a nonselective β-receptor antagonist indicated in treatment of hypertension- suffers from poor oral bioavailability due to its poor solubility and hepatic first-pass metabolism. This study aimed to optimize CARV-loaded cubosomes to enhance oral CARV bioavailability and…
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Calcipotriol Nanosuspension-Loaded Trilayer Dissolving Microneedle Patches for the Treatment of…
Psoriasis, affecting 2–3% of the global population, is a chronic inflammatory skin condition without a definitive cure. Current treatments focus on managing symptoms. Recognizing the need for innovative drug delivery methods to enhance patient adherence, this study explores a new approach using…
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Evaluation of binders in twin-screw wet granulation – Optimization of tabletability
Abstract
The influence of hydroxypropyl cellulose type (HPC-SSL SFP, HPC-SSL), concentration (2 %, 3.5 %, 5 %) and filler (lactose, calcium hydrogen phosphate (DCP)/microcrystalline cellulose (MCC)) on twin-screw wet granulation and subsequent tableting was studied. The aim was to identify the…
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Novel nano-in-micro fabrication technique of diclofenac nanoparticles loaded microneedle patches for…
Abstract
Diclofenac, a nonsteroidal anti-inflammatory drug, is commonly prescribed for managing osteoarthritis, rheumatoid arthritis, and post-surgical pain. However, oral administration of diclofenac often leads to adverse effects. This study introduces an innovative nano-in-micro approach to…
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Development of immediate-release formulation with reliable absorption of rivaroxaban in various meal…
The bioavailability of rivaroxaban at the higher doses (15 and 20 mg) is considerably reduced when the drug is administered on an empty stomach. This can lead to inadequate anticoagulant effect, and therefore, it is recommended to use the higher doses at fed state. However, proper posology may…
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Development of Oral Tablets of Nebivolol with Improved Dissolution Properties, Based on Its…
Abstract
New oral tablets of nebivolol have been developed aiming to improve, by cyclodextrin (CD) complexation, its low solubility/dissolution properties—the main reason behind its poor/variable oral bioavailability. Phase-solubility studies, performed using βCD and highly-soluble βCD-derivatives,…
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Carbomer Hydrogels with Microencapsulated α-Tocopherol: Focus on the Biocompatibility of the…
The microencapsulation of α-tocopherol based on the complex coacervation of low-molecular-weight chitosan (LMWC) and sodium lauryl ether sulphate (SLES) without harmful crosslinkers can provide biocompatible carriers that protect it from photodegradation and air oxidation. In this study, the…
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Transfer of a rational formulation and process development approach for 2D inks for pharmaceutical…
The field of pharmaceutical 3D printing is growing over the past year, with Spitam® as the first 3D printed dosage form on the market. Showing the suitability of a binder jetting process for dosage forms. Although the development of inks for pharmaceutical field is more trail and error based,…
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