Browsing Category
Merck
3D printing of amorphous solid dispersions: A comparison of fused deposition modeling and…
Nowadays, a high number of pipeline drugs are poorly soluble and require solubility enhancement by e.g., manufacturing of amorphous solid dispersion. Pharmaceutical 3D printing has great potential in producing amorphous solid oral dosage forms. However, 3D printing techniques differ greatly in terms…
Read More...
Read More...
Meeting Challenges of Pediatric Drug Delivery: The Potential of Orally Fast Disintegrating Tablets…
A majority of therapeutics are not available as suitable dosage forms for administration to pediatric patients. The first part of this review provides an overview of clinical and technological challenges and opportunities in the development of child-friendly dosage forms such as taste masking,…
Read More...
Read More...
Super disintegrating oromucosal nanofiber patch of zolmitriptan for rapid delivery and efficient…
Oromucosal administration of zolmitriptan using electrospun nanofiber can potentially result in blood plasma concentrations analogous to intravenous kinetics and targeting the brain due to anatomical features of the delivery site. Herein, we report the optimization of zolmitriptan and…
Read More...
Read More...
Preparation, Characterization and Evaluation of Flavonolignan Silymarin Effervescent Floating Matrix…
The convenient and highly compliant route for the delivery of active pharmaceutical ingredients is the tablet. A versatile platform of tablets is available for the delivery of therapeutic agents to the gastrointestinal tract. This study aimed to prepare gastro retentive drug delivery floating…
Read More...
Read More...
Formulation development and optimization of prasugrel final dosage form by direct compression method
Abstract
Background:
Prasugrel is a member of thienopyridine class of ADP receptors that reduce the aggregation ("Clumping") of platelets by irreversibly binding to P2Y12 receptors.
Objective:
The aim of this study is to develop new formulation of Prasugrel tablets by direct compression…
Read More...
Read More...
Effect of co-processed excipient type on properties of orodispersible tablets containing captopril,…
An important feature of orodispersible tablets (ODTs) is the convenient administration of the drugs, in some cases, faster onset of action, stability maintenance, and dose precision. This work focused on the preparation of ODTs containing mannitol-based co-processed excipients Prosolv® ODT G2,…
Read More...
Read More...
Hydrogel-forming microarray patch mediated transdermal delivery of tetracycline hydrochloride
Antibiotic resistance is one of the most serious health problems today and is expected to worsen in the coming decades. It has been suggested that antibiotic administration routes that bypass the human gut could potentially tackle this problem. In this work, an antibiotic hydrogel-forming microarray…
Read More...
Read More...
Oligonucleotide Formulations Prepared by High-Speed Electrospinning: Maximizing Loading and…
The aim of this study was to develop antisense oligonucleotide tablet formulations using high-speed electrospinning. Hydroxypropyl-beta-cyclodextrin (HPβCD) was used as a stabilizer and as an electrospinning matrix. In order to optimize the morphology of the fibers, electrospinning of various…
Read More...
Read More...
Hot Melt Extruded Posaconazole-Based Amorphous Solid Dispersions—The Effect of Different Types of…
Four model polymers, representing (i) amorphous homopolymers (Kollidon K30, K30), (ii) amorphous heteropolymers (Kollidon VA64, KVA), (iii) semi-crystalline homopolymers (Parteck MXP, PXP), and (iv) semi-crystalline heteropolymers (Kollicoat IR, KIR), were examined for their effectiveness in…
Read More...
Read More...
Utilization of experimental design in the formulation and optimization of hyaluronic acid–based…
Numerous problems affect oral health, and intensive research is focused on essential oil–based nanoemulsions that might treat prevent or these problems. Nanoemulsions are delivery systems that enhance the distribution and solubility of lipid medications to targeted locations. Turmeric (Tur)- and…
Read More...
Read More...