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Merck
Definitive Agreement to Acquire Exelead will Strengthen Merck’s CDMO Offering for mRNA
Merck has signed a definitive agreement to acquire Exelead, a biopharmaceutical contract development and manufacturing organization (CDMO), for approximately USD 780 million in cash.
Targeted acquisition to accelerate novel modalities service offering
Exelead, a full-service CDMO, focusing…
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Oral administration of buparvaquone nanostructured lipid carrier enables in vivo activity against…
Leishmaniasis, a neglected tropical disease, is prevalent in 98 countries with the occurrence of 1.3 million new cases annually. The conventional therapy for visceral leishmaniasis requires hospitalization due to the severe adverse effects of the drugs, which are administered parenterally.…
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3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development,…
Gelatin-polyvinylpyrrolidone (PVP) and gelatin-poly(vinyl alcohol) (PVA) mucoadhesive buccal films loaded with propranolol hydrochloride (PRH) were prepared by semi-solid extrusion 3D printing. The aim of this study was to evaluate the effects of the synthetic polymers PVP and PVA on thermal and…
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Prediction of quality attributes (mechanical strength, disintegration behavior and drug release) of…
High shear wet granulation is commonly applied technique for commercial manufacturing of tablets. Granulation process for tablets manufacturing is generally optimized by hit and trial which involves preparation of granules under different processing parameters, compression of granules and evaluation…
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Application of Dry Granulation to Facilitate Raw Material Handling
Pharmaceutical and biopharmaceutical manufacturing relies on the timely and seamless orchestration of many steps to meet aggressive timelines and ensure operational efficiency. A fundamental element of the processing workflow that can impact schedules is the use of multi-ton quantities of bulk raw…
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On-demand webinar: 3D printing of tablets – A new era of pharmaceutical manufacturing
Additive manufacturing is gaining increasing attention in the field of pharmaceutical manufacturing. Evaluations are mainly driven by advances in individualized therapy and fast track development of clinical trial material. Melt based systems provide the additional advantage of enhancing the…
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A 3D-Printed Polymer–Lipid-Hybrid Tablet towards the Development of Bespoke SMEDDS Formulations
3D printing is a rapidly growing area of interest within pharmaceutical science thanks to its versatility in creating different dose form geometries and drug doses to enable the personalisation of medicines. Research in this area has been dominated by polymer-based materials; however, for poorly…
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Development of Lipid-Based Gastroretentive Delivery System for Gentian Extract by Double…
Gentian (Gentiana lutea L., Gentianaceae) root extract (GRE) is used for the treatment of gastrointestinal disorders. However, its bioactive potential is limited in conventional forms due to the low bioavailability and short elimination half-life of the dominant bioactive compound, gentiopicroside.…
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Improved Bioavailability of Poorly Water-Soluble Drug by Targeting Increased Absorption through…
Itraconazole (ITZ) is a class II drug according to the biopharmaceutical classification system. Its solubility is pH 3-dependent, and it is poorly water-soluble. Its pKa is 3.7, which makes it a weak base drug. The aim of this study was to prepare solid dispersion (SD) pellets to enhance the release…
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Preparation, optimization and evaluation of transdermal therapeutic system of celecoxib to treat…
The purpose of present study was to prepare transdermal therapeutic system that could enhance dissolution of poorly aqueous soluble drug Celecoxib and thus increase its skin permeation. Solubility studies screened triacetin as oil, cremophor RH 40 as surfactant and Polyethylene Glycol 400 as…
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