Browsing Category
Merck
Formulation and In Vivo Evaluation of a Solid Self-Emulsifying Drug Delivery System Using Oily…
Self-emulsifying drug delivery systems (SEDDS) can improve the oral bioavailability of poorly water-soluble drugs. Solid self-emulsifying drug delivery systems (s-SEDDS) offer several advantages including improved drug stability, ease of administration, and production. Most compounds employed in…
Read More...
Read More...
Downstream processing of spray-dried ASD with hypromellose acetate succinate – Roller compaction and…
Despite wide commercial application of hypromellose acetate succinate (HPMCAS) in spray-dried amorphous solid dispersion (ASD) drug products, little information is available in the references on downstream processing of spray-dried dispersions with HPMCAS. Poor flow and high dilution factor are a…
Read More...
Read More...
Biologic excipients: Importance of clinical awareness of inactive ingredients
Due to the complexity and fragility of biological drug products, several challenges exist in their formulation development. Excipients are added to increase product stability, maintain tonicity, and facilitate drug delivery. The potential implications of these additive substances merit clinical…
Read More...
Read More...
Study of rheological and tableting properties of lubricated mixtures of co-processed dry binders for…
Co-processed dry binders for ODTs are important multifunctional excipients for tablet manufacturing by direct compression. Testing their binary mixtures with lubricants is an important aspect of their use in combination with drugs. The aim of this study was to evaluate the rheological and…
Read More...
Read More...
Design of Biopharmaceutical Formulations Accelerated by Machine Learning
In addition to activity, successful biological drugs must exhibit a series of suitable developability properties, which depend on both protein sequence and buffer composition. In the context of this high-dimensional optimization problem, advanced algorithms from the domain of machine learning are…
Read More...
Read More...
White paper: Viscosity reducing excipients for protein formulation
Protein viscosity is one of the major obstacles in preparing highly concentrated protein formulations suitable for subcutaneous (subQ) injection. Highly viscous protein solutions would require a significant force to be applied to the syringe for injection. As a result, the patient could experience a…
Read More...
Read More...
A Promising Single Oral Disintegrating Tablet for Co-Delivery of Pitavastatin Calcium and Lornoxicam…
Significance: Statins are an important class of drugs that help to control hyperlipidemia, and one of these statins recently used is pitavastatin calcium (PITA). Nevertheless, the most reported adverse effect of statins is myopathy. Therefore, combining statins with non-steroidal anti-inflammatory…
Read More...
Read More...
Pullulan film incorporated with nanocapsules improves pomegranate seed oil anti-inflammatory and…
This study aimed to prepare pullulan films containing pomegranate seeds oil (PSO) based nanocapsules, and evaluate the formulation efficacy in the treatment of atopic dermatitis (AD)-like lesions induced by 2,4-dinitrochlorobenzene (DNCB). The Eudragit RS 100® nanocapsules (PSONC) were prepared by…
Read More...
Read More...
Viscosity Reduction Platform by Merck
Carrying out intended dosing regimens often require highly concentrated protein formulations that may be too viscous for subcutaneous administration or other routes of administration that are limited by volume. While reducing viscosity with a single excipient can be ineffective or compromising…
Read More...
Read More...
In vivo evaluation of a novel zero order drug releasing transdermal system of rotigotine
Background: Rotigotine is a new non-ergolinic dopamine agonist used in the treatment of Parkinson's disorder and restless legs syndrome. It has extensive pre-systemic metabolism and administration of rotigotine through transdermal route is the best way to avoid pre-systemic metabolism and thereby to…
Read More...
Read More...