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Merck
The interactions in ternary system made of xanthan gum, Carbopol 940 and anionic/nonionic surfactant
The development and optimization of systems consist of polymers and surfactants are strongly related to the presence of interactions between them. Therefore, the interpolymer complexes between biopolymer xanthan gum and synthetic polymer Carbopol 940 were investigated before and after the addition…
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RespiCellTM: An Innovative Dissolution Apparatus for Inhaled Products
To overcome some of the shortfalls of the types of dissolution testing currently used for pulmonary products, a new custom-built dissolution apparatus has been developed. For inhalation products, the main in vitro characterisation required by pharmacopoeias is the deposition of the active…
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Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing…
One of the challenges for developing three-dimensional printed medicines is related to their stability due to the manufacturing conditions involving high temperatures. This work proposed a new protocol for preformulation studies simulating thermal processing and aging of the printed medicines,…
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Monitoring of high-load dose formulations based on co-processed and non co-processed excipients
This work presents the evaluation of a co-processed material for high-load dose formulations and its real-time monitoring by near-infrared (NIR) spectroscopy at the tablet press feed frame. The powder and tableting properties of co-processed material blends were evaluated and compared to the blend…
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Solid dispersions: improving drug performance through tablet micro-structure design
Purpose Solid dispersions formulations manufactured by Hot-Melt-Extrusion (HME) have shown to improve drug release for BCS class II drugs, such as Mefenamic acid (MFA). Drug release for MFA is highly dependent on particle size. Commercially available MFA capsules have shown high variability in their…
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Formulation design, production and characterisation of solid lipid nanoparticles (SLN) and…
Lipid nanoparticles have been widely investigated for their use as either carriers for poorly water soluble actives or as (Pickering) emulsion stabilisers. Recent studies have suggested that the fabrication of lipid nanostructures that can display both these performances concurrently, can enable the…
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Utilization of Ethylcellulose Microparticles with Rupatadine Fumarate in Designing Orodispersible…
Minitablets in orodispersible form constitute a flexible drug delivery tool for paediatric and geriatric population as they eliminate the risk of chocking and do not require drinking water in the application. Due to their direct contact with taste buds, taste sensation is an important factor.…
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Stabilizing proteins with high-purity excipients
Shield your protein of interest from challenging conditions throughout the manufacturing process and increase shelf life with Merck's high purity stabilizers. Learn how you can minimize regulatory and quality-associated risks in your biopharmaceutical manufacturing.
Stabilizers – for biomolecule…
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Evaluation of Transmission Raman spectroscopy and NIR Hyperspectral Imaging for the assessment of…
The objective of the present study was to explore and compare fast and non-destructive Transmission Raman Spectroscopy (TRS) and Near Infrared Hyperspectral imaging (NIR HSI) for the development of predictive quantitative methods to determine content uniformity (CU) of tablets.
Methods
A…
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See the overview of Parteck® Functional Excipients
When you design a solid dosage form, there are many factors to consider: the active ingredient, bioavailability enhancement, release kinetics, specific dosage, packaging, shelf life, and more.
Our Parteck® excipients were designed with the formulator’s challenges in mind and are particle…
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