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Merck
Spray-Congealing and Wet-Sieving as Alternative Processes for Engineering of Inhalation Carrier…
Purpose
Traditionally, α-lactose monohydrate is the carrier of choice in dry powder inhaler (DPI) formulations. Nonetheless, other sugars, such as D-mannitol, have emerged as potential alternatives. Herein, we explored different particle engineering processes to produce D-mannitol carriers for…
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Physico-chemical Modification of Gelatine for the Improvement of 3D Printability of Oxidized…
This work explored 3D bioplotting to mimic the intrinsic hierarchical structure of natural articular cartilage. Alginate dialdehyde-gelatine (ADA-GEL) was used as a hydrogel ink to create hierarchically ordered scaffolds. In comparison to previously reported ADA-GEL compositions, we introduce a…
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Continuous downstream processing of milled electrospun fibers to tablets monitored by near-infrared…
Electrospinning is a technology for manufacture of nano- and micro-sized fibers, which can enhance the dissolution properties of poorly water-soluble drugs. Tableting of electrospun fibers have been demonstrated in several studies, however, continuous manufacturing of tablets have not been realized…
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Enabling the direct compression of metformin hydrochloride through QESD crystallization
Metformin hydrochloride is a drug used in the treatment of type 2 diabetes. It shows very poor flowability and agglomeration under storage so that a direct compression of the material into tablets has not yet been successfully realized. In a previous study the authors showed that a quasi-emulsion…
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Exploring the Myth of Inert Excipients
Introduction
Stable active pharmaceutical ingredients (APIs) represent a critical success factor for drug formulation for four main reasons.
Firstly, the potential instability of APIs can represent a critical threat to patient safety. This risk can be generated through the decline in the actual…
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Development and evaluation of a composite dosage form containing desmopressin acetate for buccal…
Desmopressin acetate (DDAVP) is an oligopeptide indicated for the treatment of primary nocturnal enuresis, for example. The poor oral bioavailability of DDAVP accelerated a shift to alternative routes of administration like nasal and oromucosal, whereby nasal administration results in high…
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Nanostructured micronized solid dispersion of crystalline-amorphous metronidazole embedded in…
In this study metronidazole drug was encapsulated by hydroxypropyl methylcellulose and polyvinylpyrrolidone polymers from solutions using nano spray drying technology. The influence of the process parameters and formulation variables were investigated on product morhology and structure, production…
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Do we need to replace Titanium Dioxide in Pharmaceutical Formulations?
Update from October 7th: News on EU commission's decision:
On what have the member states voted on 7 October and what are the next steps?
"The Member States have expressed a favourable opinion, in the context of a Standing Committee on Plants, Animals, Food and Feed, on a proposal by the European…
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Polyvinyl Alcohol/Chitosan Single-Layered and Polyvinyl Alcohol/Chitosan/Eudragit RL100…
A novel nanofiber insert was prepared with a modified electrospinning method to enhance the ocular residence time of ofloxacin (OFX) and to provide a sustained release pattern by covering hydrophilic polymers, chitosan/polyvinyl alcohol (CS/PVA) nanofibers, with a hydrophobic polymer, Eudragit RL100…
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Screening pharmaceutical excipient powders for use in commercial 3D binder jetting printers
Binder jetting is an additive manufacturing technique that creates three-dimensional constructs from a powder feedstock. It is used by several industries, including pharmaceuticals. This additive approach to manufacture provides several functional benefits that are not easily achievable using…
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