Merck

Oropharyngeal candidiasis (OPC) is a mucosal infection caused by Candida spp., and it is common among the immunocompromised. This condition is mainly treated using oral antifungals. Chlorhexidine (CHD) is a fungicidal and is available as a mouth wash and oral gel. It is used as an adjuvant in the…
Read More...

Targeting celecoxib to the ileo-colonic region could be beneficial for the treatment and prevention of colon cancer. Ileo-colonic targeting can be achieved by using pH-dependent coating systems such as ColoPulse. Celecoxib has poor aqueous solubility, which may jeopardize optimal treatment.…
Read More...

Introduction: Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently, polymer based amorphous formulations manufactured by spray drying, hot melt extrusion (HME), or coprecipitation are…
Read More...

This study concerned the quality of mini-tablets’ coating uniformity obtained by either the bottom spray chamber with a classical Wurster distributor (CW) or a swirl distributor (SW). Mini-tablets with a diameter of 2.0, 2.5, and 3.0 mm were coated with hypromellose using two different inlet air…
Read More...

The use of a mixture of polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) was investigated for microwave-induced in situ amorphization of celecoxib (CCX) inside compacts. Such amorphization requires the presence of a dipolar excipient in the formulation to ensure heating of the compact by…
Read More...

Introduction: Tablets are still the most widely used dosage form for oral application due to their simple administration and relatively low manufacturing costs. One main disadvantage of tablets is the difficulty in swallowing or chewing. This is especially relevant for special patient groups, e.g.…
Read More...

In the next weeks, several very interesting webinars for the excipient community are scheduled. Here, we made a short overview and explanation for some of them: Our webinars: ZoomLab™: Digitally guiding dosage form and formulation for improved solubility Tuesday, 8 June – 09:00 AM EST / 03:00 PM…
Read More...

In the present study, we report the development of poly (vinyl alcohol) (PVA) and chitosan oligosaccharide (COS)-based novel blend films. The concentration of COS was varied between 2.5–10.0 wt% within the films. The inclusion of COS added a brown hue to the films. FTIR spectroscopy revealed that…
Read More...

Lipids are the most widely used delivery system for mRNA therapeutics. Lipid nanoparticles (LNPs) provide a safe and effective drug delivery system to target COVID-19 and other diseases. Watch Merck's animated video about lipid nanoparticles and lipids here: Your global partner for the…
Read More...

11 - 14 May 2021 | Online Conference Due to the COVID crisis, the 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology and its accompanying exhibition ResearchPharm® will be held online. A lot of our partners will, among others, participate at the 12th PBP World…
Read More...