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Merck
Effect of carrier type and Tween® 80 concentration on the release of silymarin from amorphous solid…
Silymarin is a mixture of flavonolignans obtained from the seeds of milk thistle (Silybum marianum L. Gaertner). Silymarin behaves as a weak acid and is categorised as a class IV drug substance in accordance with biopharmaceutics drug disposition classification system, possessing low solubility, as…
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Excipients in the Paediatric Population: A Review
This theoretical study seeks to critically review the use of excipients in the paediatric population. This study is based on the rules and recommendations of European and American drug regulatory agencies. On the one hand, this review describes the most frequent excipients used in paediatric…
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The Development and Optimization of Hot-Melt Extruded Amorphous Solid Dispersions Containing…
Rivaroxaban (RXB), a novel oral anticoagulant that directly inhibits factor Xa, is a poorly soluble drug belonging to Biopharmaceutics Classification System (BCS) class II. In this study, a hot-melt extruded amorphous solid dispersion (HME-ASD) containing RXB is prepared by changing the drug:polymer…
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Effect of Carrier Type and Tween® 80 Concentration on the Release of Silymarin from Amorphous Solid…
Silymarin is a mixture of flavonolignans obtained from the seeds of milk thistle (Silybum marianum L. Gaertner). Silymarin behaves as a weak acid and is categorised as a class IV drug substance in accordance with biopharmaceutics drug disposition classification system, possessing low solubility, as…
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Meclizine-loaded nanostructured lipid carriers to manage nausea and vomiting: Oral bioavailability…
Meclizine shows poor oral bioavailability and slow onset of action due to its low water solubility and poor permeability. In the present study, meclizine-loaded nanostructured lipid carriers (NLCs) were developed to improve oral bioavailability of meclizine. NLCs were prepared using Gelucire…
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Exploring the role of mesoporous silica nanoparticle in the development of novel drug delivery…
The biocompatible nature of mesoporous silica nanoparticles (MSN) attracted researchers’ attention to deliver therapeutic agents in the treatment of various diseases, where their porous nature, high drug loading efficiency, and suitability to functionalize with a specific ligand of MSN helped to…
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In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for…
In this study a 3D printed capsule designed to break from the physiological pressures in the antropyloric region was evaluated for its ability to deliver the synthetic octapeptide octreotide in beagle dogs when co-formulated with the permeation enhancer sodium caprate. The pressure sensitive…
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3D-printing of solid lipid tablets from emulsion gels
Interest in 3D-printing technologies for pharmaceutical manufacturing of oral dosage forms is driven by the need for personalized medicines. Most research to date has focused on printing of polymeric-based drug delivery systems at high temperatures. Furthermore, oral formulation development is…
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Challenges of Dissolution Methods Development for Soft Gelatin Capsules
Recently, the development of soft gelatin capsules (SGCs) dosage forms has attracted a great deal of interest in the oral delivery of poorly water-soluble drugs. This is attributed to the increased number of poorly soluble drugs in the pipeline, and hence the challenges of finding innovative ways of…
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Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation…
The suitability of pharmaceutical binders for continuous twin-screw wet granulation was investigated as the pharmaceutical industry is undergoing a switch from batch to continuous manufacturing. Binder selection for twin-screw wet granulation should rely on a scientific approach to enable efficient…
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