Browsing Category
Merck
Investigating the influence of various plasticiser on the properties of Kollicoat® SR 30 D based…
INTRODUCTION
Plasticiser play a decisive role in the application of functional films, especially, if an aqueous dispersion containing a water insoluble polymer is used. For the water insoluble sustained release film forming polymer PVAc, both elongation at break and minimum film forming temperature…
Read More...
Read More...
Intranasal Nanoemulsions for Direct Nose-to-Brain Delivery of Actives for CNS Disorders
The treatment of various central nervous system (CNS) diseases has been challenging, despite the rapid development of several novel treatment approaches. The blood–brain barrier (BBB) is one of the major issues in the treatment of CNS diseases, having major role in the protection of the brain but…
Read More...
Read More...
Tablet Excipients – Virtual Video Lessons in Hindi & English by Dr. Tarun Virmani
We provide this virtual lessons by Dr. Tarun Virmani, Associate Professor, MVN University, especially for our Indian Audience.
Drug products usually contain inactive, non-medicinal substances other than the therapeutic agent(s). These substances are called excipients, and they are…
Read More...
Read More...
Investigation of hydroxypropyl-β-cyclodextrin inclusion complexation of two poorly soluble model…
The goal for any formulation design of poorly soluble drugs is to increase the solubility. However, increased solubility is a challenge when the drug is administered to the oral cavity as rapidly dispersing or mucoadhesive buccal films. Most drugs are bitter and increased solubility may correlate…
Read More...
Read More...
Implementing Feedback Granule Size Control in a Continuous Dry Granulation Line Using Controlled…
In continuous manufacturing of pharmaceuticals, dry granulation is of interest because of its large throughput capacity and energy efficiency. In order to manufacture solid oral dosage forms continuously, valid control strategies for critical quality attributes should be established. To this date,…
Read More...
Read More...
Process optimization of twin-screw melt granulation of fenofibrate using design of experiment (DoE)
The purpose of this study was to optimize the melt granulation process of fenofibrate using twin-screw granulator. Initial screening was performed to select the excipients required for melt granulation process. A 3 × 3 factorial design was used to optimize the processing conditions using the % drug…
Read More...
Read More...
Measurement and quantification of caking in excipients and food products with emphasis on the…
Whilst caking occurs via several different mechanisms, absorption and migration of moisture is frequently the most dominant mechanism within the food and pharmaceutical industry. Fully understanding the propensity to cake is important for minimising down-stream process issues, however most…
Read More...
Read More...
Drug-Loaded Lipid-Core Micelles in Mucoadhesive Films as a Novel Dosage Form for Buccal…
The aim of the study was to develop a novel buccal dosage form to transport rhodamine 123 and human insulin as models for poorly water-soluble and biological drugs, using lipid-core micelles (LCMs)-loaded mucoadhesive films. LCMs were synthesized by a low-energy hot emulsification process, yielding…
Read More...
Read More...
On the particle formation of leucine in spray drying of inhalable microparticles
The particle formation of L-leucine, a dispersibility-enhancing amino acid used in the spray drying of inhalable pharmaceutical aerosols, was extensively studied using three experimental methods, and the results were interpreted with the aid of theory. A comparative-kinetics electrodynamic balance…
Read More...
Read More...
Disintegrant Selection in Hydrophobic Tablet Formulations
The hydrophobicity of poorly soluble drugs can delay tablets disintegration. We probed here the influence of different disintegrants on the disintegration of challenging hydrophobic formulations. Tablets containing diluents, hydrogenated vegetable oil and either sodium starch glycolate (SSG),…
Read More...
Read More...