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Merck
Creation of Filaments for 3D Printing via Hot Melt Extrusion: Evaluating Different Downstream…
Purpose: For several years now 3D printing technology has been gaining increasing attention within the pharmaceutical industry. The number of publications is rapidly increasing. One promising 3D printing technology is the fused deposition modeling where a polymer strand is heated and extruded…
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Design of propolis-loaded film forming systems for topical administration: The effect of acrylic…
In situ film forming systems are an alternative to the conventional dosage forms for topical application, performing superior contact and adhesiveness, with a consequent sustained and efficacious therapy. Propolis (PRP) is an extremely versatile natural compound due to its constitutive complexity…
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Development and Characterization of Pullulan-based Orally Disintegrating Films Containing Amlodipine…
The aim of this study was to prepare pullulan-based orally disintegrating films (ODFs) containing amlodipine besylate, an anti-hypertensive drug, by the solvent casting method. For this purpose, nine different ODF formulations (F1-F9) were prepared by using different plasticizers (glycerol,…
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Opportunities for Successful Stabilization of Poor Glass-Forming Drugs: A Stability-Based Comparison…
Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently, polymer-based amorphous formulations manufactured by spray drying, hot melt extrusion (HME), or co-precipitation are most common.…
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Towards a Continuous Manufacturing Process of Protein-Loaded Polymeric Nanoparticle Powders
To develop a scalable and efficient process suitable for the continuous manufacturing of poly(lactic-co-glycolic acid) (PLGA) nanoparticles containing ovalbumin as the model protein. PLGA nanoparticles were prepared using a double emulsification spray-drying method. Emulsions were prepared using a…
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Successful Drug Development with Synthetic Lipids: Critical Aspects and Strategies
pharma's almanac - September 29, 2020 PAP-Q3-20-CL-024 - Shiksha Mantri, Ph.D. - Adela Kasselkus, Ph.D.
Lipid-based drug delivery systems offer several advantages, including improving the stability, solubility, bioavailability, and toxicity profiles of active pharmaceutical ingredients (APIs). It…
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Pre-treatment with high molecular weight free PEG effectively suppresses anti-PEG antibody induction…
Immune responses against polyethylene glycol (PEG) can lead to the rapid clearance of PEGylated drugs and are associated with increased risk of serious adverse events such as infusion reactions and anaphylaxis. Although select PEGylated therapeutics can induce anti-PEG antibodies (APA), there is…
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Abuse deterrent immediate release film technology (ADRIFT): A novel bilayer film technology for…
Prescription opioid abuse also known as opioid epidemic has been an ever-growing problem in the United States. It has been associated with numerous emergencies and mortality with significant burden on healthcare system. Amongst various approaches proposed by FDA, development of an abuse deterrent…
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Influence of Polyvinyl Alcohol (PVA) on PVA-Poly-N-hydroxyethyl-aspartamide (PVA-PHEA)…
This study was conducted to formulate buccal films consisting of polyvinyl alcohol (PVA) and poly-N-hydroxyethyl-aspartamide (PHEA), to improve the dissolution of the drug through the oral mucosa. Ibuprofen sodium salt was used as a model drug, and the buccal film was expected to enhance its…
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Formulation design and pharmacokinetic evaluation of docosahexaenoic acid containing…
Docosahexaenoic acid is a omega-3-fatty acid which together with other long-chain omega-3-fatty acid known to have protective effect against various diseases including hypertension, myocardial infarction, Alzheimer disease, and cancers. Poor bioavailability owning to limited aqueous solubility…
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