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Merck
Effect of Different Direct Compaction Grades of Mannitol on the Storage Stability of Tablet…
This study tested 15 direct compaction grades to identify the contribution of different grades of mannitol to the storage stability of the resulting tablets. After preparing the model tablets with different values of hardness, they were stored at 25 °C, 75% relative humidity for 1 week. Then,…
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Imaging of the Effect of Alcohol-Containing Media on the Performance of Hypromellose Hydrophilic…
As the ingestion of drug products with alcohol could have adverse effects on the release of drugs from dosage forms, it is important to understand the mechanisms underpinning the influence on drug release by evaluating the effect of alcohol-containing media on the behaviour of pharmaceutical…
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What is the Role of Over 100 Excipients in Over the Counter (OTC) Cough Medicines?
by Eccles, R. What is the Role of Over 100 Excipients in Over the Counter (OTC) Cough Medicines?. Lung (2020). https://doi.org/10.1007/s00408-020-00390-x
Most medicines are white bitter powders that are formulated as tablets and capsules but cough medicines are an exception where the taste and…
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The inorganic polymer, polyphosphate, blocks binding of SARS-CoV-2 spike protein to ACE2 receptor at…
Inorganic polyphosphate (polyP) is a morphogenetically active and metabolic energy-delivering physiological polymer that is released from blood platelets. Here, we show that polyP efficiently inhibits the binding of the envelope spike (S)-protein of the coronavirus SARS-CoV-2, the causative agent of…
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A Novel Composite Dosage Form for Buccal Drug Administration
The potential of alternative routes of application compared to the traditional oral route is constantly growing. Especially in transmucosal applications for the oral cavity, easy accessibility is an attractive feature with many new opportunities.
The combination of a minitablet and a buccal…
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Cellulose and its derivatives for application in 3D printing of pharmaceuticals
Background
Three-dimensional printing (3DP) has emerged as an advanced manufacturing technology capable of producing complex yet precise medicines intended for patient-centric drug therapy. However, printable materials currently available for 3DP are far too limited.
Area covered
The current…
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Raman Spectroscopy as a PAT-Tool for Film-Coating Processes: In-Line Predictions Using one PLS Model…
Although Raman spectroscopy has been described as a potential process analytical technique for tablet coating, it has rarely been transferred from academic studies to commercial manufacturing applications. The reasons for this are probably not only the high level of process understanding and…
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Comparison between twin-screw and high-shear granulation – The effect of filler and active…
Highlights
• Twin-screw granulation was less sensitive for liquid amount used.
• API compaction properties had only minor effect on the tablet tensile strength.
• Tablets made of TSG granules had a higher tensile strength than HSG tablets.
• Twin-screw granulation is a good…
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Hot-Melt Extrusion as an Advantageous Technology to Obtain Effervescent Drug Products
Here, we assessed the feasibility of hot-melt extrusion (HME) to obtain effervescent drug products for the first time. For this, a combined mixture design was employed using paracetamol as a model drug. Extrudates were obtained under reduced torque (up to 0.3 Nm) at 100 °C to preserve the stability…
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Application of polyvinyl acetate in an innovative formulation strategy for lyophilized orally…
Orally disintegrating tablets (ODTs) manufactured by freeze-drying, also called oral lyophilizates, are a patient-centred dosage form. They possess ultra-fast disintegration dynamics, have acceptable mechanical strength and have a smooth mouth texture. In this study, polyvinyl alcohol (PVA) was…
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