Browsing Category
Merck
Development and evaluation of solid dispersion based rapid disintegrating tablets of poorly…
Glimepiride is an effective oral hypoglycemic agent that lowers the glucose level of blood by stimulating insulin release from beta cells of the pancreas. However, the poor aqueous solubility (i.e., <0.004 mg/ml) and wettability of drugs pose hurdles in the formulation of drug delivery vehicles.…
Read More...
Read More...
Spray dried VSV-vectored vaccine is thermally stable and immunologically active in vivo
Effective vaccine delivery and coverage to rural and resource-poor countries is hindered by the dependence on cold chain storage. As such, developments of cold chain-free technologies are highly sought. Although spray dried adenoviral vectors have shown long term stability at ambient temperatures…
Read More...
Read More...
The EsoCap-system – An innovative platform to drug targeting in the esophagus
For the therapy of esophageal diseases such as eosinophilic esophagitis, there are no possibilities of local targeted therapy. This publication describes a novel, innovative drug delivery concept, that enables a targeted, long-lasting administration of drug substances to the esophageal mucosa. In…
Read More...
Read More...
Effect of the molecular mobility of water adsorbed by disintegrants on storage-induced hydrolytic…
The purpose of this study was to investigate the effect of molecular mobility of water adsorbed by disintegrants on the hydrolytic degradation of active pharmaceutical ingredients (APIs). Fourteen different disintegrants were tested. First, powdered disintegrants were stored at conditions of 40…
Read More...
Read More...
Introduction of the energy to break an avalanche as a promising parameter for powder flowability…
Dynamic avalanche testing is a newer method useful even with cohesive powder samples. To evaluate flow properties of pharmaceutical powder excipients, break energy (BE) is introduced as a new promising avalanche parameter. Conventional pharmacopoeial methods and an annular shear cell were utilized…
Read More...
Read More...
Porous Nanostructure, Lipid Composition, and Degree of Drug Supersaturation Modulate In Vitro…
The unique nanostructured matrix obtained by silica-lipid hybrids (SLHs) is well known to improve the dissolution, absorption, and bioavailability of poorly water-soluble drugs (PWSDs). The aim of this study was to investigate the impact of: (i) drug load: 3–22.7% w/w, (ii) lipid type: medium-chain…
Read More...
Read More...
Tabletting Solid Dispersions of Bicalutamide Prepared Using Ball-milling or Supercritical Carbon…
The studies were aimed at formulating tablets containing bicalutamide-PVP K-29/32 solid dispersions and accessing the interrelationships between the properties of obtained binary systems in the form of powder and compacts. The effect of the compression of the solid dispersions obtained by either…
Read More...
Read More...
Fabrication of Montelukast sodium loaded filaments and 3D printing transdermal patches onto…
The main objectives of this work were to develop and characterize new 3D printing filaments and print them directly onto a packaging material. Different blends of polymers were tested to achieve low-temperature printing filaments, which are flexible and durable to be wound onto spools. The…
Read More...
Read More...
Pediatric dosage forms—challenges and recent developments: A critical review
Pediatric population is a diverse group comprising of different subgroups. The use of unlicensed and off-label medicines for treating children is widespread due to the non-availability of suitable dosage forms for this age group. Although the physiological differences related to the diverse age…
Read More...
Read More...
Essential oils: a review on their salient biological activities and major delivery strategies
Essential oils are volatile, complex products of plants as secondary metabolites and include terpenes and their oxygenated derivatives, such as alcohols, aldehydes, esters, ketones, phenols and oxides. In recent years, out of 3000 essential oils obtained from plant origin only 300 essential oils…
Read More...
Read More...