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Merck
Pharmacokinetic Investigation of Synthetic Cannabidiol Oral Formulations in Healthy Volunteers
Recent advances in the research of medicinal cannabis has placed the non-intoxicating cannabinoid cannabidiol (CBD) at the front of many investigations. The reasons behind this popularity is the compound’s therapeutic properties, alongside a safe profile of administration lacking addictive…
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Performance tuning of particle engineered mannitol in dry powder inhalation formulations
Typically, smooth lactose particles are used as carrier in dry powder formulations for inhalation. Two classical approaches to improve their aerodynamic behaviour are the addition of fines (milled lactose) or magnesium stearate (MgSt). Mannitol (Parteck® M DPI) as an alternative carrier was used in…
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Dermal Pharmacokinetics of rivastigmine-loaded liposomes: an Ex vivo- in vivo correlation study
The aim of the present study was to develop a topical liposomal formulation as a transdermal delivery of rivastigmine for the treatment of Alzheimer disease as an alternative to the oral dosage form and to achieve smooth continuous drug delivery and maintain plasma levels within the therapeutic…
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High-Dose Methotrexate-Induced Idiopathic Intracranial Hypertension in Infant Acute Lymphoblastic…
A 7-month-old female patient with B-cell acute lymphoblastic leukemia (ALL) developed recurring anterior fontanelle bulging after completing both of her first and second courses of high-dose methotrexate (HD-MTX) induction. She did not, however, show any other abnormal neurological examinations,…
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Development and characterisation of novel poly (vinyl alcohol)/poly (vinyl pyrrolidone)-based…
Highlights
Novel hydrogel-forming microneedles were produced.
Their physicochemical properties were promising.
Methotrexate was successfully delivered in vitro and in vivo.
Methotrexate (MTX) is one of the mainstays of treatment for rheumatoid arthritis (RA) and juvenile idiopathic…
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Temperature and Solvent Facilitated Extrusion Based 3D Printing for Pharmaceuticals
On demand manufacturing of patient-specific oral doses provides significant advantages to patients and healthcare staff. Several 3D printing (3DP) technologies have been proposed as a potential digital alternative to conventional manufacturing of oral tablets. For additive manufacturing approach to…
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StarLac® for Orally Disintegrating Tablets
Oral application of drugs is not only the most common way for systemic drug application, it is also patient’s route of choice. Oral formulations are – compared to injections or infusions – convenient and painless. As they do not require sterility they are cost effective and reveal good patient…
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Enhanced Oral Bioavailability of Felodipine from Solid Lipid Nanoparticles Prepared Through…
Felodipine (FLD), a dihydropyridine calcium channel blocker with excellent antihypertensive effect, is poorly soluble and undergoes extensive hepatic metabolism, which lead to poor oral bioavailability (about 15%) and limit its clinic application. The goal of this study was to develop solid lipid…
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Human mouthfeel panel investigating the acceptability of electrospun and solvent cast orodispersible…
A human panel study was performed to investigate the acceptability of orodispersible electrospun and solvent cast films. 50 healthy volunteers took two drug-free samples of polyvinyl alcohol films prepared by the two methods. On a 5-point hedonic scale, the volunteers assessed the films’ perceived…
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Development and Characterization of Liquisolid Tablets Based on Mesoporous Clays or Silicas for…
The aim of this work was to evaluate the effectiveness of mesoporous clays or silicas to develop fast-dissolving glyburide tablets based on a liquisolid approach. Selected clay (Neusilin®US2) and silica (Aeroperl®300) allowed preparation of innovative drug liquisolid systems containing…
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