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Merck
Effect of common excipients on intestinal drug absorption in Wistar rats
The aim of the present paper is to study the effect of common excipients on the permeability of atenolol (as drug absorbed mainly by passive diffusion) and rhodamine (as P-Glycoprotein substrate). Apparent permeability was measured by in situ perfusion method in Wistar rats using the Closed loop…
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Parteck® Coat: When coating runs smoothly – Reduce coating time with optimized particle…
Parteck® COAT Excipient - Start rapidly, coat flexibly.
It can be a challenge to find the right coating for your formulation, and it can be even more frustrating when your workflow is restrained due to slow processing times. With Parteck® COAT, you get the right coating adapted to your needs and…
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Quality by Design thinking in the development of long-acting injectable PLGA/PLA-based microspheres…
Adopting the Quality by Design (QbD) approach in the drug development process has transformed from ‘nice-to-do’ into a crucial and required part of the development, ensuring the quality of pharmaceutical products throughout their whole life cycle. This review is discussing the implementation of the…
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Metformin Hydrochloride- and Glyburide-Containing Orally Disintegrating Tablets
Diabetes is characterized by chronic hyperglycemia. Although metformin hydrochloride (MHCl)- and glyburide (GLB)-containing conventional tablets are available in the market and used to treat diabetes, orally disintegrating tablets (ODTs) containing the combination of these drugs are not commercially…
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Rheological & Suspending Properties of Commonly Used Oral Suspending Vehicles
Little is documented about the rheology of commonly oral used suspending vehicles (which include everything from water through commercial suspending agents to semi-solid foods such as yoghurt which are often used in the administration of medicines to children). Following on from this, little is…
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The Stabilizing Excipients in Dry State Therapeutic Phage Formulation
Phage therapy has gained prominence due to the increasing pathogenicity of “super bugs” and the rise of their multidrug resistance to conventional antibiotics. Dry state formulation of therapeutic phage is attractive to improve their “druggability” by increasing their shelf life, improving their…
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Characterization of ternary amorphous solid dispersion containing hypromellose phthalate and…
Hot melt extrusion is a promising technology for producing amorphous solid dispersions, however, there is a risk of thermal degradation or residual crystallinity formation. This caveat may be addressed by optimizing formulations and manufacturing conditions. The aim of our study was to explore…
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Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status,…
Polymer-based nanocapsules have been widely studied as a potential drug delivery system in recent years. Nanocapsules—as one of kind nanoparticle—provide a unique nanostructure, consisting of a liquid/solid core with a polymeric shell.
This is of increasing interest in drug delivery applications.…
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A physiologically-based drug absorption modeling for orally disintegrating tablets
The aim of this research was to simulate oral pharmacokinetic (PK) profiles of atorvastatin from orally disintegrating tablets (ODTs) dosed without water ingestion in fasted humans. The in vitro dissolution profiles of three different formulations of ODTs were evaluated with fasted state biorelevant…
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Compaction behavior of isomalt after roll compaction
Isomalt is a polyol derived from sucrose. Advantages of this excipient are its sweet taste, which is supposed to allow taste masking, the low glycemic and insulinemic response (Petzoldt, 1982), and the ability to be compacted directly. With regard to infantile patients, also the lack of…
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