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Merck
Lyophilisation Improves Bioactivity and Stability of Insulin-Loaded Polymeric-Oligonucleotide…
The oral bioavailability of therapeutic proteins is limited by the gastrointestinal barriers. Encapsulation of labile proteins into nanoparticles is a promising strategy. In order to improve the stability of nanoparticles, lyophilisation has been used to remove water molecules from the suspension.…
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Influence of the Punch Speed on the Die Wall/Powder Kinematic Friction During Tableting
Influence of the compaction speed on the final tablet properties is an important challenge during the scale-up of a solid dosage form. This strain rate sensitivity is generally attributed to the time dependent deformation behavior of the powder. In this work, we studied the influence of the speed on…
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Development of solid lipid nanoparticle as carrier of pioglitazone for amplification of oral…
Pioglitazone (PGL) is a hypoglycemic therapeutic agent used in the treatment of diabetes (type 2). The present research work was designed to prepare and optimize PGL loaded solid lipid nanoparticles (SLNs). The formulation was optimized using three factors lipid (Compritol® 888 ATO - A), surfactant…
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Effect of the third component on the aging and crystallization of cinnarizine-soluplus® binary solid…
Multiple carriers may be used to prepare solid dispersions (SDs) for different purposes. The aim of this work is to investigate the effect of the third component on the physical stability and physical aging behavior of cinnarizine-soluplus SDs. HPMC, PVP, sorbitol and citric acid were used as the…
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Model-dependent pharmacokinetic analysis of enalapril following the administration of novel…
Despite the legislative initiatives by the regulatory European medical agency (EMA) and the United States Food and Drug Administration Authority (FDA), an approved drug with child-appropriate dosage formulations are still absent for many drugs for pediatric heart failure. The pediatric patients are…
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Tableting of hot-melt coated paracetamol granules: Material tableting properties and quality…
Hot-melt coating (HMC) has been recognized as a promising technique in the production of solid dosage forms e.g., HMC of granules can be applied prior to compression in order to obtain modified drug release or taste masking. However, tableting properties of HMC granules have not been studied yet. In…
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INFLUENCE OF BINDER ATTRIBUTES ON BINDER EFFECTIVENESS IN A CONTINUOUS TWIN SCREW WET GRANULATION…
As a switch to continuous twin screw granulation is quickly gaining momentum, the suitability of binders needs to be evaluated towards this novel granulation process. Binder suitability depends on binder effectiveness, which is affected by binder attributes. These critical attributes need to be…
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Safety Assessment of Excipients (SAFE) for Orally Inhaled Drug Products
The development of new orally inhaled drug products requires the demonstration of safety which must be proven in animal experiments. New in vitro methods may replace, or at least reduce, these animal experiments provided they are able to correctly predict the safety or eventual toxicity in humans.…
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PVA in Sustained Release Matrix Tablets – Wet Granulated vs Direct Compression – Poster
Polymer-based long-acting matrix tablets are often used to ensure patient compli- ance and API efficacy of orally applied drugs. Increasingly, polyvinyl alcohols (PVAs) are used as hydrophilic, swellable and erodible matrices in such sustained release (SR) tablets, as they show a prolonged API…
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Partially hydrolyzed polyvinyl alcohol for fusion-based pharmaceutical formulation processes:…
The present study evaluates the effect of several pharmaceutical plasticizers on the thermo-physical and physicochemical properties of partially hydrolyzed poly(vinyl alcohol) (PVA) used in fusion-based pharmaceutical formulation processes.
Specifically, the effect of mannitol (MAN), sorbitol…
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