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Merck
Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron
The aim of this work was to explore the feasibility of using selective laser sintering (SLS) 3D printing (3DP) to fabricate orodispersable printlets (ODPs) containing ondansetron. Ondansetron was first incorporated into drug‐cyclodextrin complexes and then combined with the filler mannitol.
Two…
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Mechanistic aspects of drug loading in liquisolid systems with hydrophilic lipid-based mixtures
Despite the increasing interest in pharmaceutical use of mesoporous silica, there is still only limited knowledge on mechanisms of pore loading and subsequent drug desorption and release. Hence the aim of this work was to address the mechanistic aspects of drug loading into the mesoporous silica…
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Non-destructive dose verification of two drugs within 3D printed polyprintlets
Three-dimensional printing (3DP) is a revolutionary technology in pharmaceuticals, enabling the personalisation of flexible-dose drug products and 3D printed polypills (polyprintlets). A major barrier to entry of this technology is the lack of non-destructive quality control methods capable of…
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Benznidazole Self-Emulsifying Delivery System: A Novel Alternative Dosage Form For Chagas Disease…
Benznidazole (BZ) tablets are a unique form of treatment available for treating Chagas disease. Development of a liquid formulation containing BZ easy to administer orally for the treatment of paediatric patients, particularly for newborns is urgently required, with the same efficacy, safety and…
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Mechanistic insights into effect of surfactants on oral bioavailability of amorphous solid…
Drug delivery of poorly soluble drugs in form amorphous solid dispersions (ASDs) is an appealing method to increase in vivo bioavailability. For rational formulation design, a mechanistic understanding of the impact of surfactants on the performance of ASD-based formulations is therefore of…
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The Importance of Amorphous Stability: Mesoporous Silica for Poor Glass Formers – Webinar
Manufacturing Strategies Webinar Series
The Importance of Amorphous Stability: Mesoporous Silica for Poor Glass Formers
This webinar will discuss the theory of amorphous stabilization followed by a discussion on mesoporous silica as an emerging approach for optimal stabilization of poor glass…
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Co-processed excipients for direct compression of tablets
Tablets are the most frequently employed dosage form. Their advantage lies in their availability, easy administration, good stability, and low price. The easiest technology to produce tablets is direct compression, even though the use of the method requires overcoming many obstacles, mainly related…
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Comparative dissolution studies on granules with acetaminophen and caffeine using the basket and…
Acetaminophen and caffeine, popular therapeutic substances used to relieve pain or alleviate the symptoms of cold.
The aims of the study were the comparison of granules, in terms of dissolution rate and moreover the development of spectrophotometric method to the simultaneous determination of…
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Production of Directly Compressible Excipients With Mannitol By Wet Granulation: Rheological,…
The purpose of this research was to produce co-processed excipients using mannitol as base material with some of the most used binders: potato, maize pre-gelatinized starch, and K-25, K-29/32, K-90 povidone.
Mannitol, one commercial based mannitol product, and the produced materials were…
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Numerical study for tableting process in consideration of compression speed
A numerical study of the tableting process using a finite element method (FEM) is important to quantitatively understand the structural change inside the tablet and the mechanism of tableting failures such as capping, picking, lamination, and sticking. In the pharmaceutical field, the Drucker-Prager…
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