Merck

Many functional substances are hardly dissolved in water or lipid at ambient temperature, which causes some difficulties in product formulation. Therefore, the aim of this research was to develop a novel carrier system by complexing nanostructured lipid carriers (NLC) with mesoporous silica…
Read More...

The present research work summarises the development of an in situ gelling ophthalmic nanoemulsion of brinzolamide providing sustained release and prolonged therapeutic effect for the treatment of glaucoma. Nanoemulsions were prepared using castor oil, polyoxyl 35 castor oil and polysorbate 80…
Read More...

The need to improve the solubility of active pharmaceutical ingredients (APIs) has been rising for decades. Today, this need is increasingly pressing, as the number of APIs that are poorly water-soluble (based on their BCS classification) is growing: while around 40% of APIs on the market show poor…
Read More...

Purpose: Novel tablet coating approaches include the development of continuous coating technologies. This requires a high level of automation to assure the quality and safety of the final coated product. Despite automation of control procedures also approaches of in-line process analytical…
Read More...

Purpose: Polyvinyl alcohol (PVA) is a well-established polymer for film coating. PVA is a synthetic, bio-compatible and toxicologically well characterized polymer. It is frequently used in pre-mixed coating formulations. Fixed combinations with additional ingredients are well established. By…
Read More...

Epilepsy is a brain disorder that affects millions of people worldwide and is usually managed using currently available antiepileptic drugs, which result in adverse effects and are ineffective in approximately 20-25% of patients. Thus, there is growing interest in the development of new…
Read More...

Mesoporous silica has emerged as an enabling formulation for poorly soluble active pharmaceutical ingredients (APIs). Unlike other formulations, mesoporous silica typically does not inhibit precipitation of supersaturated API therefore, a suitable precipitation inhibitor (PI) should be added to…
Read More...

Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently, polymer-based amorphous formulations manufactured by spray drying, hot melt extrusion (HME), or co-precipitation are…
Read More...

The Challenges of Determining Excipient Quality In the past years, the critical role of excipients in drug production has come into focus. This meant shaking off the long prevailing perception of excipients being passive additions to an active pharmaceutical ingredient (API). Now regulatory…
Read More...

The aim of this study was to solidify a ticagrelor loaded self-microemulsifying drug delivery system (TCG-SM) with enhanced dissolution and bioavailability of ticagrelor (TCG) for developing TCG-SM granules and tablets. TCG was dissolved in the self-microemulsifying drug delivery system (SMEDDS)…
Read More...