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Merck
The Effect of Formulation Variables on the Manufacturability of Clopidogrel Tablets via Fluidized…
Solid pharmaceutical formulations with class II active pharmaceutical ingredients (APIs) face dissolution challenges due to limited solubility, affecting in vivo behavior. Robust computational tools, via data mining, offer valuable insights into product performance, complementing traditional methods…
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Co-release of paclitaxel and encequidar from amorphous solid dispersions increase oral paclitaxel…
The oral bioavailability of paclitaxel is limited due to low solubility and high affinity for the P-glycoprotein (P-gp) efflux transporter. Here we hypothesized that maximizing the intestinal paclitaxel levels through apparent solubility enhancement and controlling the simultaneous release of both…
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Evaluation of the effect of polymer composition on the rheological, mechanical properties and drug…
Capsules have been investigated as a popular oral dosage form among communities due to their simplicity and ease of production. Capsules that are considered in the gastro-resistance category can be very beneficial due to enhanced drug absorption, improved stability, targeted release, etc. This study…
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Studying the API Distribution of Controlled Release Formulations Produced via Continuous Twin-Screw…
Abstract
Hydroxypropyl methylcellulose (HPMC) is a preferred hydrophilic matrix former for controlled release formulations produced through continuous twin-screw wet granulation. However, a non-homogeneous API distribution over sieve fractions with underdosing in the fines fraction (<150 µm) was…
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Advanced analysis of disintegrating pharmaceutical compacts using deep learning-based segmentation…
Abstract
The mechanism governing pharmaceutical tablet disintegration is far from fully understood. Despite the importance of controlling a formulation's disintegration process to maximize the active pharmaceutical ingredient's bioavailability and ensure predictable and consistent release…
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A systematic investigation of external lubrication of mini-tablets on a rotary tablet press with…
Abstract
External lubrication is an alternative to internal lubrication and its related detrimental effects on properties of tablets like tensile strength (TS). However, to date there are hardly any systematic investigations on external lubrication of mini-tablets on rotary tablet presses. Aim of…
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Fabrication of Orally Fast Disintegrating Wafer Tablets Containing Cannabis Extract Using Freeze…
Abstract
Introduction: The development of a novel dosage form for cannabis extract is necessary to improve drug delivery
and to also enhance patient convenience.
Methods: Orally fast disintegrating wafer tablets containing cannabis extract, which were prepared using the
freeze drying…
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Development and characterization of solid lipid-based formulations (sLBFs) of ritonavir utilizing a…
As a high number of active pharmaceutical ingredients (APIs) under development belong to BCS classes II and IV, the need for improving bioavailability is critical. A powerful approach is the use of lipid-based formulations (LBFs) that usually consist of a combination of liquid lipids, cosolvents,…
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Mirtazapine loaded polymeric micelles for rapid release tablet: A novel formulation – In vitro…
Major depression is a prevalent disorder characterized by sadness, lack of interest or pleasure, interrupted sleep or food, and impaired concentration. Mirtazapine (MTZ), a tetracyclic antidepressant drug, is commonly used to treat moderate to severe depression. MTZ is classified as a BCS class II…
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Development of a New Bioequivalent Omeprazole Product
Abstract
Background and Objectives: The enteric form of omeprazole is one of the most commonly prescribed medications. Similarly to Europe, Kazakhstan relies on the localization of pharmaceutical drug production as one of its primary strategies to ensure that its population has access to affordable…
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