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Merck
Simultaneous photo-induced polymerization and surface modification by microfluidic spinning to…
Functionalized polymer fibers were prepared by microfluidic spinning involving simultaneous photopolymerization and surface modification. A capillary-based microfluidic device was used with two miscible coaxially co-flowing phases to afford polymer fibers by the photopolymerization of poly(ethylene…
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Nose-to Brain Delivery of Resveratrol, a Non-Invasive Method for the Treatment of Cerebral Ischemia
Abstract
Cerebral ischemia represents a particular condition among neurological diseases due to its high frequency, high associated mortality, and the permanent disability in patients that survive it. Numerous studies in animal models have demonstrated the protective properties of resveratrol…
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A Comprehensive Review of Disintegrants: Backbone of disintegration
Abstract
Strong attractive bonding forces works among the particles of solid dosage forms such as mechanical, solid and intermolecular and bioavailability of solid dosage form is preferentially dependent on in vivo disintegration then dissolution. This review is focused for disintegrating agents,…
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Inhaled dry powder liposomal azithromycin for treatment of chronic lower respiratory tract infection
A dry powder inhaled liposomal azithromycin formulation was developed for the treatment of chronic respiratory diseases such as cystic fibrosis and bronchiectasis. Key properties including liposome size, charge and encapsulation efficiency powder size, shape, glass transition temperature (Tg), water…
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Comparison of Different Sorbitol Sorbitan Solutions as Gelatin Plasticizer
INTRODUCTION
Soft capsules are a popular dosage form for dispensing active pharmaceutical or nutraceutical materials. The shell material is frequently composed of gelatin, softened with considerable amount of plasticizer. They are especially adapted for liquids and for the formulation of hardly…
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Mechanistic Insight in Permeability through Different Membranes in the Presence of Pharmaceutical…
The present study reports the effects of two pharmaceutical excipients of differing natures—non-ionic surfactant pluronic F127 (F127) and anionic sulfobutylether-β-cyclodextrin (SBE-β-CD)—on the permeation of the model compound, carbamazepine (CBZ). The permeability coefficients of CBZ at three…
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W/O/W microemulsions for nasal delivery of hydrophilic compounds: a preliminary study
The administration of hydrophilic therapeutics has always been a great challenge because of their low bioavailability after administration. For this purpose, W/O/W microemulsion resulted to be a potential successful strategy for the delivery of hydrophilic compounds, interesting for the nasal…
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In Vitro and Biological Evaluation of Oral Fast-Disintegrating Films Containing Ranitidine HCl and…
Flurbiprofen (FBP), a nonsteroidal anti-inflammatory drug (NSAID), is commonly used to treat the pain of rheumatoid arthritis, but in prolonged use it causes gastric irritation and ulcer. To avoid these adverse events of NSAIDs, the simultaneous administration of H2 receptor antagonists such as…
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Chitosan coated lipid carriers as nanoplatform for repurposed anti-breast cancer activity of…
Drug repurposing is promising strategy with niclosamide showing encouraging results against breast cancer. However, niclosamide hydrophobicity limits its oral bioavailability and minimizes its anti-cancer activity. Nano-structured lipid carriers (NLCs) showed enhance therapeutic performance coping…
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Taste Masking of Dexketoprofen Trometamol Orally Disintegrating Granules by High-Shear Coating with…
Abstract
Orally disintegrating granules (ODGs) are a pharmaceutical form commonly used for the administration of NSAIDs because of their easy assumption and fast dispersion. The development of ODGs is not easy for drugs like dexketoprofen trometamol (DXKT), which have a bitter and burning taste. In…
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