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Formulation development, in-vitro and ex-vivo evaluation of dry adsorbed solid lipid nanoparticles:…
Abstract
Aim: The present study was aimed at preparing stable dry adsorbed nanoparticles (DANs) of olanzapine (OLZ) loaded solid lipid nanoparticles (SLNs) for sustained release.
Materials/methods: OLZ SLNs were prepared by hot melt emulsification and ultrasonication using Precirol ATO 5 (PRE)…
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Shin-Etsu AQOAT® – Enteric coating polymer and solid dispersion carrier
Shin-Etsu supplies the various excipients for pharmaceutical industry. Let us introduce you Shin-Etsu AQOAT® Hypromellose acetate succinate (HPMCAS, NF, JP), an enteric coating material that can be used in aqueous or organic media.
Hypromellose is a non-toxic material which has been used in…
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Closer to the Formulator (C2F) – A Center of Excellence by DFE Pharma
DFE Pharma is a global leader in pharma and nutraceutical excipient solutions. They develop, produce and supply high quality functional excipients for use in the pharmaceutical, biopharmaceutical, and nutraceutical industries for respiratory, oral solid dose (OSD), ophthalmic and parenteral…
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Polymeric Amorphous Solid Dispersions of Dasatinib: Formulation and Ecotoxicological Assessment
Abstract
Dasatinib (DAS), a potent anticancer drug, has been subjected to formulation enhancements due to challenges such as significant first-pass metabolism, poor absorption, and limited oral bioavailability. To improve its release profile, DAS was embedded in a matrix of the hydrophilic polymer…
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Suppression of Related Substance in Tablets Containing Pressure-Sensitive Drugs with Elongated…
This poster was presented at the PBP World Meeting in Vienna 2024 by Asahi-Kasei
INTRODUCTION
It is known that the pressure, friction, heat, etc. applied during compression molding of some drugs causes crystal distortion and destabilization.
When dealing with such kinds of substances,…
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Paediatric clinical study of 3D printed personalised medicines for rare metabolic disorders
Rare diseases are infrequent, but together they affect up to 6–10 % of the world’s population, mainly children. Patients require precise doses and strict adherence to avoid metabolic or cardiac failure in some cases, which cannot be addressed in a reliable way using pharmaceutical compounding. 3D…
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SEPPIC Introduces SEPINEO P 600 Polymer for Topical Application
SEPINEO™ P 600 is multifunctional: thickening, emulsifying, stabilizing and texturing agent. Acrylamide/Sodium Acryloyldimethyl Taurate Copolymer/Isohexadecane & Polysorbate 80. Ready-to-use, it is designed for the formulation such as gels and creams and is very easy to implement.
SEPINEO™ P…
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Transdermal Delivery of Pramipexole Using Microneedle Technology for the Potential Treatment of…
Parkinson’s disease (PD) is a debilitating neurodegenerative disease primarily impacting neurons responsible for dopamine production within the brain. Pramipexole (PRA) is a dopamine agonist that is currently available in tablet form. However, individuals with PD commonly encounter difficulties with…
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Solid self-emulsifying casein carrier for the improvement on the oral bioavailability of simvastatin
Simvastatin (SV) is a statin drug that can effectively control cholesterol and prevent cardiovascular diseases. However, SV is water-insoluble, and poor oral bioavailability (<5 %). Solid self-emulsifying carrier system is more stable than liquid emulsions, facilitating to improve the solubility…
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BIOHALE® – Products for the Stabilization of Biologics
BioHale® is DFE Pharma´s, high-purity, low-endotoxin product portfolio for the stabilization of biologics. Because stability matters.
BioHale® Key promises:
Uncompromised quality
Security of supply
Expert support
Uncompromised quality
BioHale® high purity and low endotoxin…
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