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Optimizing API Load and Minimizing Tablet Weight Leveraging an Innovative DC Mannitol
Presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical (PBP) Technology, 18 - 21 March 2024, Vienna, Austria:
INTRODUCTION
Tablets with stability issues often use mannitol, a stable, water-soluble excipient compatible with most drugs. Direct compression is a…
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Excipient Reactivity and Drug Stability in Formulations
This is about the excipient used for achieving sustained release function undergone chemical reaction with the stabilizing agent used for the drug product leading to product quality failure from the desired dissolution behavior. The generic version of Bupropion HCl SR 150 mg, i.e. sustained (12…
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Design of a Novel Delivery Efficiency Feedback System for Biphasic Dissolving Microarray Patches…
Abstract
Dissolving microarray patches (DMAPs) represent an innovative approach to minimally invasive transdermal drug delivery, demonstrating efficacy in delivering both small and large therapeutic molecules. However, concerns raised in end-user surveys have hindered their commercialization…
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Improved pharmacokinetic and lymphatic uptake of Rose Bengal after transfersome intradermal…
The lymphatic system is active in several processes that regulate human diseases, among which cancer progression stands out. Thus, various drug delivery systems have been investigated to promote lymphatic drug targeting for cancer therapy; mainly, nanosized particles in the 10–150 nm range quickly…
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Understanding the Interaction of Thermal, Rheological, and Mechanical Parameters Critical for the…
Abstract
Hot melt extrusion (HME) is a common manufacturing process used in the pharmaceutical industry to improve the solubility of poorly soluble active pharmaceutical ingredients (API). The goal is to create an amorphous solid dispersion (ASD) where the amorphous form of the API is stabilized…
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Improving Active Pharmaceutical Ingredient Formulation by Hot Melt Extrusion
This poster was presented at PBP World Meeting 2024 in Vienna:
The integration of Artificial Intelligence (AI) and big data into pharmaceutical research over the past two decades has revolutionized drug discovery, enabling the identification of therapeutic targets with high accuracy and…
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Rethinking the development of controlled release formulations and manufacturing processes –…
We invite you to our next webinar:
"Rethinking the development of controlled release formulations and manufacturing processes"
During this webinar we will cover the key topics related to controlled release formulations in drug delivery and different manufacturing processes.
We will…
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Solubility of Poorly Soluble Drugs in Phosphatidylcholine-Based Drug Delivery Systems: Comparison of…
Abstract
The aim of this study was to determine the drug loading capacity of phosphatidylcholine-based formulations for four poorly water-soluble drug substances (clofazimine, fenofibrate, artemether, cannabidiol). Two self-dispersing lipid formulations were investigated, which consisted of soybean…
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Easy Tableting with Natural Disintegrants
Evaluation of a new disintegrant mixture from natural resources
Introduction
Tablet disintegration is most often required to divide a tablet into suitably small sub-units that facilitate achievement of the desired drug dissolution rate. While semi-synthetic or synthetic super-disintegrants are…
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Parafilm® M and Strat-M® as skin simulants in in vitro permeation of dissolving microarray patches…
In vitro permeation studies play a crucial role in early formulation optimisation before extensive animal model investigations. Biological membranes are typically used in these studies to mimic human skin conditions accurately. However, when focusing on protein and peptide transdermal delivery,…
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