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Identification and structural elucidation of an oxidation product generated during stability studies…
Cabergoline is a dopamine agonist with applications as anti-Parkinson drug and prolactin inhibitor. The cabergoline drug product Laktostop® 50 µg/mL is used in veterinary medicine for lactation suppression in cats and dogs e.g. during false pregnancy. Recently, during ongoing HPLC stability testing…
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How oregano essential oil can be transformed into a taste-masking controlled release solid…
Oregano essential oil (OEO) has antioxidant, antiproliferative, anti-inflammatory and antimicrobial activities. OEO could be administered orally for some gastrointestinal diseases, however, its oral use, is severely hampered by its irritant taste, which requires a high dilution in water before…
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Designing starch-based fenofibrate formulations using the melting method
Fenofibrate (FNF) is used to treat hyperlipidemia. However, FNF is a poorly water-soluble drug, and the dosage of commercial products is relatively high at 160 mg in a Lipidil® tablet. Therefore, this study aimed to develop an FNF-solid dispersion (SD) that solubilizes and stabilizes FNF. The…
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Systematic Development of Hot Melt Extrusion-Based Amorphous Solid Dispersion: Integrating Quality…
Abstract
Purpose
The study aimed to develop and optimize apremilast (APST) solid dispersion formulations using copovidone (Kollidon VA64) as the carrier and vitamin E TPGS as the surfactant to enhance solubility and dissolution, and to utilize in silico Physiologically Based Biopharmaceutics…
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3D printed dispersible efavirenz tablets: A strategy for nasogastric administration in children
Enteral feeding tubes (EFTs) can be placed in children diagnosed with HIV which need nutritional support due to malnutrition. EFTs are the main route for medication administration in these patients, bringing up concerns about off label use of medicines, dose inaccuracy and tube clogging. Here we…
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Oral Solid Dose – Direct Comparison of Pharmacel® 101 and Pharmacel® 102
High-quality excipients
Oral Solid Dose
A comprehensive range of highly consistent excipients for OSD formulations, including a full range of lactose (milled monohydrate, sieved monohydrate, micronized, anhydrous, spray dried, and granulated), cellulosics and starches portfolio comprising of…
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Formulation and evaluation of ivermectin-loaded dissolving microarray patches for rosacea disease
Abstract
Purpose
This investigation aims to develop and characterise dissolving microarray patches (MAPs) loaded with ivermectin (IVM) for rosacea therapy.
Methods
Tween® 80 and Soluplus® were evaluated to enhance the water solubility of IVM powder. Three dissolving MAPs were fabricated using…
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Innovative Solutions in Tablet Development: MEDELPHARM and KORSCH AG’s contributions at the…
Press Release
MEDELPHARM, specialist in innovative technologies and services for powder processing, along with KORSCH AG, were present during this year’s Compaction Simulation Forum (CSF) in Dublin.
As leading sponsors, both MEDELPHARM and KORSCH showcased their scientific contributions. They…
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Comprehensive Review of Modern Techniques of Granulation in Pharmaceutical Solid Dosage Forms
ABSTRACT
This comprehensive review explores modern granulation techniques in pharmaceutical dosage forms along with conventional methods, focusing on dry granulation and wet granulation. Dry granulation techniques, including slugging, roller compaction, and pneumatic dry granulation, are…
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Design of easily swallowable xerogel pill with enough physical strength through hardening-process…
The xerogel pill has been developed as a novel dosage form with dose-adjusting and swallow-assisting functions by using drop freeze-drying (DFD) technique. It was double-structured small sphere composed of an inner drug core and an outer dried-gel layer, however, had problem of insufficient physical…
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